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Washington Huskies quarterback Michael Penix Jr. puts on an offensive clinic to start the season, as we share our best California vs. Washington prediction based on the college football odds across our best sports betting apps.

With so many returning playmakers, the 3-0 Washington Huskies should field a high-scoring offense, and quarterback Michael Penix Jr. is parlaying it into a case to be mentioned among the Heisman Trophy odds favorites.

The Huskies welcome the 2-1 California Golden Bears to Seattle this week, and Cal has shown well defensively to start the season. Problem is, there’s been no answers for Penix and the Washington offense, and we’re not anticipating the Golden Bears solving the equation, either.

To help fill out your college football Week 4 predictions, here is our best California vs. Washington prediction and our college football picks (odds via our best college football betting sites; pick confidence based on a 1-to-5-star scale).

California vs. Washington prediction: Week 4

Washington -20.5 (-110 via DraftKings) ⭐⭐⭐⭐

Even with rain in the forecast, there’s really no defense in college football that can stop the Washington passing offense.

The Huskies have the highest-rated adjusted offensive efficiency in the nation for a reason. QB Michael Penix Jr. has been on a Heisman pace, leading his offense to three 40-plus point outings by racking up more than 1,300 passing yards and 12 passing touchdowns across those three games.

Cal’s defense, though, is easily the best one the Huskies will have faced to this point in the year (if you trust FPI’s defensive efficiency metrics). Cal ranks 17th in defensive efficiency, while the other Washington opponents all rank outside the top 75. Cal has allowed just 139 passing yards per game.

Given that these numbers have come against largely dormant passing offenses, though, I’m betting that Cal truly has no way to prepare for what it's about to see. Penix hung 374 yards and two touchdowns at Cal last season; I’m expecting a dominant performance in Seattle on Saturday night.

Cal’s only hope to keep this close would be to shorten the game and make it ugly, as it did in a 14-10 loss to Auburn. But in terms of seconds per play, Cal actually runs a much faster offensive pace than Washington. Keeping the ball out of Penix’s hands isn’t statistically going to be a plausible approach with how Cal has played so far this season.

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California vs. Washington best odds

DraftKings (-110)

DraftKingsFanDuelBetMGMCaesarsbet365
Washington -20.5Washington -20.5Washington -20.5Washington -20.5Washington -20.5
-110-110-115-110-110

After the line opened above three touchdowns, it feels as though all the -20.5 offerings across our best sports betting apps carry solid value. The only shop with a knock on the quality of odds is BetMGM, which increased the odds to -115 for this spread play.

Barring a more definitive forecast for wind to render the passing style of the Huskies problematic, we would take Washington this week up to -23.5. The recommendation would reduce to a three-star play at -21.5.

California vs. Washington odds

California vs. Washington odds analysis

Washington opened as a 21.5-point favorite but has seen that number dip back down below three touchdowns across our best sports betting sites

The total opened at 62.5, but has dropped to between 59.5 and 60.5, likely as a result of rain in the forecast for Saturday evening in Seattle. 59% of the wagers on the total have come in on the Over.

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California vs. Washington game info

  • When: Saturday, Sept. 23 at 10:30 p.m. ET
  • Where: Husky Stadium, Seattle, WA
  • How to watch: ESPN
  • Weather: 61 degrees, 10 mph winds, 69% precipitation

California-Washington prediction made Thursday at 3:50 p.m. ET.

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