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We're into the fourth-to-last full week of the 2023 season as we round up all of our betting experts' top college football predictions for Week 10 based on the best college football odds. The action will once again run from Tuesday through Saturday. 

Week 10 of the college football season has a doubleheader each of Tuesday, Wednesday, and Friday with a tripleheader on Thursday. That's nine games serving as an appetizer ahead of another full college football Saturday which carries some of the most enticing matchups of the season to date.

When preparing to make your college football predictions for Week 10, be sure to study up on the College Football Championship odds, Heisman Trophy odds, and College Football Playoff odds from our best college football betting sites.

College football picks and predictions for Week 10

College football predictions for Saturday

Washington vs. USC pick: Over 76.5 points (-110 via bet365) ⭐⭐⭐⭐

Washington-USC pick made by Phil Wood

LSU vs. Alabama pick: Over 60.5 (-110 via Caesars) ⭐⭐⭐⭐

LSU-Alabama pick made by Brenden Schaeffer

Oregon State vs. Colorado pick: D.J. Uiagalelei Under 0.5 interceptions (+100 via DraftKings) ⭐⭐⭐⭐

Oregon State-Colorado pick made by Shane Jackson

College football expert picks for Week 10

College football odds pages

Here are our best college football betting sites:

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