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The last week of the college football regular season has arrived, giving underdogs one final chance to bark before conference championship week and bowl season begin.

  • Oklahoma upset Alabama as a 14.5-point underdog, marking the Sooners’ first win against a top-10 opponent when unranked since 2005
  • Florida’s win over Ole Miss as 13.5-point underdogs was its second-largest upset victory in the last 45 seasons
  • Two AP top-25 teams (Iowa State and Missouri) are less than seven-point favorites against unranked opponents 

Our college football upset picks fade two ranked opponents, and the selections call for an upset that would put an interesting wrinkle into the College Football Playoff odds picture.

College football upset picks: Week 14

College football odds as of Tuesday and subject to change. Track the college football scores for the latest line movement and matchup info.

Week 14 upset predictions

College football picks made Tuesday; odds subject to change. Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Minnesota (+110) ⭐⭐⭐⭐

Minnesota just missed a chance to secure one of its most significant upsets in recent memory, suffering a one-point loss at home to Penn State as 11.5-point underdogs last week.

While many teams would be susceptible to a hangover after a tough loss like that, I expect high-energy Gophers head coach P.J. Fleck will get his squad refocused in this battle for the Paul Bunyan Axe.

Fleck Again
Minnesota Golden Gophers head coach P.J. Fleck celebrates a blocked punt against the Penn State Nittany Lions during the second quarter at Huntington Bank Stadium. Mandatory Credit: Matt Krohn-Imagn Images

Minnesota held Penn State to 1-for-11 on third-down attempts, committed just one penalty in the game, and earned an eight-minute advantage in the time-of-possession battle. That's a recipe for success on the road against a Wisconsin team that was just bullied for 29 first downs and 478 total yards during a 19-point loss at Nebraska.

The Golden Gophers are as low as a +105 underdog through BetMGM, so the best value can be found at DraftKings.

Best odds: +110 via DraftKings | Implied probability: 47.62%

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UTSA (+235) ⭐⭐⭐

Army and UTSA have met four times since 2019, with the Black Knights winning three of those four outright. However, they've split the last two meetings, with eight or fewer points the difference each time.

Now UTSA’s explosive offense should give it a great chance to pull off this road upset.

I'm throwing out most of last year’s 37-29 home loss to Army, as the Roadrunners played that game without injured quarterback Frank Harris. UTSA has benefitted from plenty of exposure to Army’s triple-option attack, even if it's been evolving slightly over the years.

UTSA still put up 360 total yards of offense last year, despite using a backup quarterback and possessing the ball for fewer than 16 minutes. That included three touchdowns of 44-plus yards.

I expect the Roadrunners will dissect Army’s game film from its loss to Notre Dame to implement new defensive strategies to slow down Bryson Daily and the Black Knights' offense.

There's a huge 37-cent gap between the +198 odds at the low end of the market through FanDuel and the generous +235 odds offered at Caesars. A winning $10 wager if UTSA pulls off the upset would lead to $23.50 in profit through Caesars for one of your college football Week 14 predictions.

Best odds: +235 via Caesars | Implied probability: 29.85%

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Syracuse (+330) ⭐⭐

What fun would predicting upsets be if I didn't include a result that would shake up the College Football Playoff picture considerably? 

Syracuse has won all three of its home games since a bad home loss to Stanford earlier in the season while scoring 31-plus points in each. The Orange followed up an eight-point road win as double-digit underdogs against California with a tidy victory over UConn.

The Orange entered last week after allowing over 400 total yards and 30 points per game over the previous three contests. But then they held the Huskies to 24 points, 352 total yards, and 16 first downs.

Miami’s offense is going to score against Syracuse, but the Orange would feel comfortable in a shootout. Orange quarterback Kyle McCord has thrown for 395 yards per game while posting a 5-0 TD-INT ratio over the last three weeks.

DraftKings is alone among our best sportsbooks while offering better than +328 odds to back the underdog Orange.

Best odds: +330 via DraftKings | Implied probability: 23.26%

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