College Football Week 10 Predictions: Picks & Odds for Marquee Games

Rob Paul

Last Updated: November 1, 2024 5:32 AM EDT • 2 min 25 sec read. Twitter link Google News Link

Oregon Ducks quarterback Dillon Gabriel throws a football during warm ups before a game against the Illinois Fighting Illini at Autzen Stadium as we look at our College Football Week 10 predictions. — Oregon Ducks quarterback Dillon Gabriel throws a football during warm ups before a game against the Illinois Fighting Illini at Autzen Stadium. Photo by Troy Wayrynen-Imagn Images

As a whole this week's slate isn't overly spectacular, but our Week 10 college football predictions look at the games you won't want to miss, including one of the most important matchups of the year.

Ohio State plays Penn State in a game between two College Football Playoff odds contenders that could have major ramifications in the Big Ten
Oregon, led by Heisman Trophy odds favorite Dillon Gabriel, heads to the Big House to take on Michigan
At the World's Largest Outdoor Cocktail Party, college football championship odds favorite Georgia is poised to beat up on Florida

While Week 10 lacks for AP Top 25 matchups, the Buckeyes and Nittany Lions are treating us to a massive matchup on Saturday at noon ET.

College football picks & predictions Week 10

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College football odds for Saturday

College football odds via DraftKings and subject to change. Follow the latest college football scores for line history and matchup info.

Oregon vs. Michigan odds

College Football Week 10 Predictions — Oregon quarterback Dillon Gabriel leaves the field after the win over Illinois at Autzen Stadium in Eugene Saturday, Oct 26, 2024.

Prediction: Oregon -14.5 (-108 via DraftKings) vs. Michigan ⭐⭐⭐⭐

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Pick made by Phil Wood.

When: Saturday, Nov. 2 (3:30 p.m. ET)
Where: Michigan Stadium (Ann Arbor, Mich.)
How to watch: CBS, Paramount+
Moneyline: Oregon (-650) | Michigan (+470)
Spread: Oregon -15 (-110) | Michigan +15 (-110)
Total: 45 (-112/-108)

Florida vs. Georgia odds

Prediction: Georgia -14.5 (-105 via FanDuel) vs. Florida ⭐⭐⭐

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Pick made by Shane Jackson.

When: Saturday, Nov. 2 (3:30 p.m. ET)
Where: EverBank Stadium (Jacksonville, Fla.)
How to watch: ABC, ESPN+
Moneyline: Florida (+525) | Georgia (-750)
Spread: Florida +16.5 (-110) | Georgia -16.5 (-110)
Total: 52 (-110/-110)

Texas Tech vs. Iowa State odds

Prediction Rocco Becht Over 254.5 passing yards (-114 via FanDuel) ⭐⭐⭐⭐⭐

Pick made by Brenden Schaeffer

When: Saturday, Nov. 2 (3:30 p.m. ET)
Where: Jack Trice Stadium (Ames, Iowa)
How to watch: ESPN
Moneyline: Texas Tech (+410) | Iowa State (-550)
Spread: Texas Tech +14 (-112) | Iowa State -14 (-108)
Total: 55.5 (-112/-108)

College football picks roundup: Week 10

College football betting odds pages

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Written By:
Rob Paul

Rob is a Publishing Editor at Sportsbook Review. He’s been with the team since early 2024, with this being his first full-time role in the sports betting industry. Before joining SportsbookReview.com, he contributed to various sports outlets, including FanSided and Pro Football Network. During that period, he spent five years working full-time as a local community journalist, after attending Durham College for journalism and Wilfrid Laurier University for history. He previously hosted an NFL draft and college football-focused podcast where he had the opportunity to interact with future NFL players such as Maxx Crosby and Quinn Meinerz. Rob has spent multiple years working as a freelance podcast producer for numerous sports-related podcasts while making guest appearances on several college football shows. He’s also made guest appearances on SportsTalk Mississippi on several occasions to talk all things NFL draft. Rob values the way sports betting acts as a catalyst for telling stories and growing interest in certain sports, particularly FCS football, WNBA, and mid-major college basketball. He’s always been drawn to the more obscure teams and conferences in major college sports, but most of all, Rob loves using stats to find the best player props to back.