College Football Week 5 Predictions: Picks & Odds for Marquee Games
In the most significant slate of the season to date, our college football Week 5 odds and predictions highlight the notable games involving AP top 25 programs.
The best game of the week is a battle of college football championship odds favorites, with Georgia taking on Alabama.
We cover that marquee game, which kicks off at 7:30 p.m. ET, extensively, offering a prediction and player props while also dedicating a standalone piece to Jalen Milroe's props.
We're already a third of the way through the season, and the College Football Playoff odds are taking shape. And now Week 5 is among the most important weeks of the campaign for the College Football playoffs.
College football picks & predictions Week 5
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Don't miss the rest of our Week 5 college football picks.
College football odds for Saturday
College football odds via DraftKings and subject to change. Follow the latest college football scores for line history and matchup info.
Ohio State vs. Michigan State odds
Prediction: Michigan State +23.5 (-105 via BetMGM) vs. Ohio State ⭐⭐⭐
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Pick made by Phil Wood
- When: Saturday, Sept. 28 (7:30 p.m. ET)
- Where: Spartan Stadium (East Lansing, Mich.)
- How to watch: Peacock
- Moneyline: Ohio State (-2100) | Michigan State (+1100)
- Spread: Ohio State -24 (-108) | Michigan State +24 (-112)
- Total: 48.5 (-110/-110)
Georgia vs. Alabama odds
Prediction: Jalen Milroe Over 201.5 passing yards (-114 via FanDuel) ⭐⭐⭐⭐
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Pick made by Mike Spector.
- When: Saturday, Sept. 28 (7:30 p.m. ET)
- Where: Bryant-Denny Stadium (Tuscaloosa, Ala.)
- How to watch: ABC
- Moneyline: Georgia (-130) | Alabama (+110)
- Spread: Georgia -2 (-112) | Alabama +2 (-108)
- Total: 48.5 (-112/-108)
Arizona vs. Utah odds
Prediction: Brant Kuithe 2+ touchdowns (+850 via DraftKings) ⭐⭐⭐⭐
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Pick made by Brenden Schaeffer.
- When: Saturday, Sept. 28 (10:15 p.m. ET)
- Where: Rice-Eccles Stadium (Salt Lake City, Utah)
- How to watch: ESPN
- Moneyline: Arizona (+330) | Utah (-425)
- Spread: Arizona +12 (-110) | Utah -12 (-110)
- Total: 50.5 (-108/-112)
College football picks roundup: Week 5
- College football against the spread picks Week 5
- College football upset picks Week 5
- College football expert picks Week 5
- College football predictions & best bets Week 5
- College football player props Week 5
- College football public betting trends Week 5
- Big Ten predictions
- SEC predictions
- Big 12 predictions
College football betting odds pages
Here are our best college football betting sites:
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- BetMGM Bonus Code: SBRBONUS | Read our BetMGM Review
- bet365 Bonus Code: SBRBONUS | Read our bet365 Review
- FanDuel Promo Code | Read our FanDuel Review
- DraftKings Promo Code | Read our DraftKings Review
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