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Georgia linebacker Jalon Walker sacks Alabama quarterback Jalen Milroe. We break down Georgia vs. Alabama in our Week 5 college football predictions.
Georgia linebacker Jalon Walker sacks Alabama quarterback Jalen Milroe. Photo by Dale Zanine via Imagn Images.

In the most significant slate of the season to date, our college football Week 5 odds and predictions highlight the notable games involving AP top 25 programs.

The best game of the week is a battle of college football championship odds favorites, with Georgia taking on Alabama.

We cover that marquee game, which kicks off at 7:30 p.m. ET, extensively, offering a prediction and player props while also dedicating a standalone piece to Jalen Milroe's props. 

We're already a third of the way through the season, and the College Football Playoff odds are taking shape. And now Week 5 is among the most important weeks of the campaign for the College Football playoffs.

College football picks & predictions Week 5

Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Don't miss the rest of our Week 5 college football picks.

College football odds for Saturday

College football odds via DraftKings and subject to change. Follow the latest college football scores for line history and matchup info.

Ohio State vs. Michigan State odds

Prediction: Michigan State +23.5 (-105 via BetMGM) vs. Ohio State ⭐⭐⭐

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Pick made by Phil Wood

  • When: Saturday, Sept. 28 (7:30 p.m. ET)
  • Where: Spartan Stadium (East Lansing, Mich.)
  • How to watch: Peacock
  • Moneyline: Ohio State (-2100) | Michigan State (+1100)
  • Spread: Ohio State -24 (-108) | Michigan State +24 (-112)
  • Total: 48.5 (-110/-110)

Georgia vs. Alabama odds

Prediction: Jalen Milroe Over 201.5 passing yards (-114 via FanDuel) ⭐⭐⭐⭐

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Pick made by Mike Spector.

  • When: Saturday, Sept. 28 (7:30 p.m. ET)
  • Where: Bryant-Denny Stadium (Tuscaloosa, Ala.)
  • How to watch: ABC
  • Moneyline: Georgia (-130) | Alabama (+110)
  • Spread: Georgia -2 (-112) | Alabama +2 (-108)
  • Total: 48.5 (-112/-108)

Arizona vs. Utah odds

Prediction: Brant Kuithe 2+ touchdowns (+850 via DraftKings) ⭐⭐⭐⭐

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Pick made by Brenden Schaeffer.

  • When: Saturday, Sept. 28 (10:15 p.m. ET)
  • Where: Rice-Eccles Stadium (Salt Lake City, Utah)
  • How to watch: ESPN
  • Moneyline: Arizona (+330) | Utah (-425)
  • Spread: Arizona +12 (-110) | Utah -12 (-110)
  • Total: 50.5 (-108/-112)

College football picks roundup: Week 5

College football betting odds pages

Here are our best college football betting sites:

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