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Georgia linebacker Jalon Walker sacks Alabama quarterback Jalen Milroe. We break down Georgia vs. Alabama in our Week 5 college football predictions.
Georgia linebacker Jalon Walker sacks Alabama quarterback Jalen Milroe. Photo by Dale Zanine via Imagn Images.

In the most significant slate of the season to date, our college football Week 5 odds and predictions highlight the notable games involving AP Top 25 programs.

  • In a Friday night ACC showdown, Cam Ward will look to continue building on his Heisman Trophy odds lead when Miami plays Virginia Tech
  • With Texas a 38.5-point favorite at our college football betting sites, Arch Manning may get his second straight start for the Longhorns against lowly Mississippi State
  • The best game of the week is a battle of college football championship odds favorites, with Georgia taking on Alabama

We're already a third of the way through the season, and the College Football Playoff odds are taking shape. And now Week 5 is among the most important weeks of the campaign for the College Football playoffs.

College football picks & predictions Week 5

Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

  • Army vs. Temple early picks
    • Army vs. Temple prediction (coming soon)
  • Virginia Tech vs. Miami early picks
    • Virginia Tech vs. Miami prediction (coming soon)
  • Washington vs. Rutgers early picks
    • Washington vs. Rutgers prediction (coming soon)
  • Oklahoma State vs. Kansas State prediction (coming soon)
  • Minnesota vs. Michigan (coming soon)
  • Colorado vs. UCF early picks
    • Colorado vs. UCF prediction (coming soon)
    • Colorado vs. UCF player props (coming soon)
    • Shedeur Sanders player props (coming soon)
  • Louisville vs. Notre Dame prediction (coming soon)
  • Mississippi State vs. Texas early picks (coming soon)
    • Mississippi State vs. Texas prediction (coming soon)
    • Arch Manning player props (coming soon)
  • Ohio State vs. Michigan State prediction (coming soon)
  • Georgia vs. Alabama early picks
    • Georgia vs. Alabama prediction (coming soon)
    • Georgia vs. Alabama player props (coming soon)
    • Jalen Milroe player props (coming soon)
  • Arizona vs. Utah prediction (coming soon)

Don't miss the rest of our Week 5 college football picks.

College football odds for Thursday

College football odds via DraftKings and subject to change. Follow the latest college football scores for line history and matchup info.

Army vs. Temple odds

  • When: Thursday, Sept. 26 (7:30 p.m. ET)
  • Where: Lincoln Financial Field (Philadelphia, Pa.)
  • How to watch: ESPN
  • Moneyline: Army (-535) | Temple (+400)
  • Spread: Army -13 (-112) | Temple +13 (-108)
  • Total: 45.5 (-110/-110)

College football odds for Friday

Virginia Tech vs. Miami odds

  • When: Friday, Sept. 27 (7:30 p.m. ET)
  • Where: Hard Rock Stadium (Miami Gardens, Fla.)
  • How to watch: ESPN
  • Moneyline: Virginia Tech (+700) | Miami (-1100)
  • Spread: Virginia Tech +19.5 (-110) | Miami -19.5 (-110)
  • Total: 55 (-112/-108)

Washington vs. Rutgers odds

  • When: Friday, Sept. 27 (8 p.m. ET)
  • Where: SHI Stadium (Piscataway, N.J.)
  • How to watch: FOX
  • Moneyline: Washington (+124) | Rutgers (-148)
  • Spread: Washington +3 (-115) | Rutgers -3 (-105)
  • Total: 44.5 (-108/-112)

College football odds for Saturday

Oklahoma State vs. Kansas State odds

  • When: Saturday, Sept. 28 (noon ET)
  • Where: Bill Snyder Family Stadium (Manhattan, Kans.)
  • How to watch: ESPN
  • Moneyline: Oklahoma State (+154) | Kansas State (-185)
  • Spread: Oklahoma State +4.5 (-108) | Kansas State -4.5 (-112)
  • Total: 55.5 (-108/-112)

Minnesota vs. Michigan odds

  • When: Saturday, Sept. 28 (noon ET)
  • Where: Michigan Stadium (Ann Arbor, Mich.)
  • How to watch: FOX
  • Moneyline: Minnesota (+275) | Michigan (-345)
  • Spread: Minnesota +9 (-110) | Michigan -9 (-110)
  • Total: 36 (-112/-108)

Colorado vs. UCF odds

  • When: Saturday, Sept. 28 (3:30 p.m. ET)
  • Where: FBC Mortgage Stadium (Orlando, Fla.)
  • How to watch: FOX
  • Moneyline: Colorado (+425) | UCF (-575)
  • Spread: Colorado +15 (-112) | UCF -15 (-108)
  • Total: 63 (-110/-110)

Louisville vs. Notre Dame odds

  • When: Saturday, Sept. 28 (3:30 p.m. ET)
  • Where: Notre Dame Stadium (Notre Dame, Ind.)
  • How to watch: Peacock
  • Moneyline: Louisville (+185) | Notre Dame (-225)
  • Spread: Louisville +6 (-108) | Notre Dame -6 (-112)
  • Total: 47 (-110/-110)

Mississippi State vs. Texas odds

  • When: Saturday, Sept. 28 (4:15 p.m. ET)
  • Where: DKR-Texas Memorial Stadium (Austin, Tex.)
  • How to watch: SEC Network
  • Moneyline: OFF
  • Spread: Mississippi State +38.5 (-108) | Texas -38.5 (-112)
  • Total: 62.5 (-105/-115)

Ohio State vs. Michigan State odds

  • When: Saturday, Sept. 28 (7:30 p.m. ET)
  • Where: Spartan Stadium (East Lansing, Mich.)
  • How to watch: Peacock
  • Moneyline: Ohio State (-2100) | Michigan State (+1100)
  • Spread: Ohio State -24 (-108) | Michigan State +24 (-112)
  • Total: 48.5 (-110/-110)

Georgia vs. Alabama odds

  • When: Saturday, Sept. 28 (7:30 p.m. ET)
  • Where: Bryant-Denny Stadium (Tuscaloosa, Ala.)
  • How to watch: ABC
  • Moneyline: Georgia (-130) | Alabama (+110)
  • Spread: Georgia -2 (-112) | Alabama +2 (-108)
  • Total: 48.5 (-112/-108)

Arizona vs. Utah odds

  • When: Saturday, Sept. 28 (10:15 p.m. ET)
  • Where: Rice-Eccles Stadium (Salt Lake City, Utah)
  • How to watch: ESPN
  • Moneyline: Arizona (+330) | Utah (-425)
  • Spread: Arizona +12 (-110) | Utah -12 (-110)
  • Total: 50.5 (-108/-112)

College football picks roundup: Week 5

  • College football against the spread picks Week 5
  • College football upset picks Week 5 (coming soon)
  • College football expert picks Week 5 (coming soon)
  • College football predictions & best bets Week 5 (coming soon)
  • College football player props Week 5 (coming soon)
  • Big Ten predictions (coming soon)
  • SEC predictions (coming soon)
  • Big 12 predictions (coming soon)

College football betting odds pages

Here are our best college football betting sites:

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