Cubs vs. Astros Prediction, Odds & Best Bets: Battle of Division Leaders

Kyle Tucker continues to face his former team on Saturday night after his Cubs fell to the Astros yesterday. Can he get revenge today?

Mike Spector

Last Updated: June 28, 2025 11:36 AM EDT • 3 minute read

Cubs vs. Astros Prediction, Odds & Best Bets: Saturday, June 28 — Pictured: Houston Astros third baseman Isaac Paredes headlines our Cubs vs. Astros prediction for Saturday night. Photo by Maria Lysaker via Imagn Images.

Two division leaders meet in the middle game of a three-game set, as the Houston Astros (49-33) host the Chicago Cubs (48-34) as -125 moneyline favorites.

We make our Cubs vs. Astros prediction, odds, and best bets with first pitch at 7:15 p.m. ET (FOX) from Daikin Park in Houston.

Cubs vs. Astros prediction: Cubs to win (+106 via FanDuel) ⭐⭐⭐⭐
Over/Under prediction: Over 8.5 (-120 via BetMGM) ⭐⭐⭐⭐
Best player prop pick: Isaac Paredes to hit a home run (+390 via bet365) ⭐⭐⭐

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✅ Best bet: Isaac Paredes to hit a home run (+390 via bet365)

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The Astros entered Friday’s series opener having won 12 of their last 15 games, with pitching being a big part of their success (team 2.86 ERA over that span). However, given Cubs righty Colin Rea’s susceptibility to giving up home runs, Houston should be in for a successful day offensively.

Rea is one of 26 starting pitchers who've allowed 13-plus home runs this season. But he is also one of two on that list who have done so in fewer than 74 innings, and all have come since May 1. After not allowing a home run over his first six appearances, he is on pace for a HR/9 rate of 1.6 or worse for the sixth consecutive season.

Paredes leads the Astros with 16 home runs, and his .828 OPS against right-handed pitchers is second on the team. Thirteen of his 16 home runs have come against righties, and he is a good bet to hit a home run for just the second time in 12 games, considering Rea allowed four long balls in his previous start.

Bettors stand to earn a payout of $5 more on a $10 wager by making this wager at bet365, whose +390 odds would pay out $39 in profits on a winning wager compared to the $34 based on Caesars’ +340 odds.

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Written by:
Mike Spector

Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”