Cubs vs. Twins Prediction, Odds & Best Bets: Can Chicago Avoid Its First Road Sweep?

The Twins will be looking to complete a sweep of the Chicago Cubs this afternoon in Minnesota.

Mike Spector

Last Updated: July 10, 2025 9:49 AM EDT • 4 minute read

Pictured Minnesota Twins left fielder Harrison Bader celebrates, and he'll be key in our Cubs vs. Twins Prediction. Photo by Matt Krohn / Imagn.

After taking the first two games of this three-game series from the Chicago Cubs, the Minnesota Twins have now won consecutive home series for the first time since their 13-game winning streak in May. Our Cubs vs. Twins prediction for this game at Target Field scheduled for 1:10 p.m. ET (MLBN) analyzes whether they can complete the sweep.

All of our best MLB betting sites have moved their moneyline odds massively in Chicago’s favor after opening the contest as a coin-flip game, so that's an angle we play up as part of our Cubs vs. Twins best bets.

Cubs vs. Twins prediction: Cubs to win (-126 via FanDuel) ⭐⭐⭐⭐
Best Cubs vs. Twins player props: Harrison Bader to hit a home run (+750 via DraftKings) ⭐⭐⭐

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✅ Cubs vs. Twins prediction: Cubs to win (-126 via FanDuel)

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Chicago righty Colin Rea’s numbers might not jump off the page, but lately when he toes the rubber his team wins. That's why I am backing the road team with my Cubs vs. Twins prediction.

The Cubs are 5-1 in Rea’s last six starts, and 6-2 in the eight games he's pitched on the road. And it’s not like Chicago has played a cupcake schedule in that stretch, with wins over two division leaders (the Houston Astros and Philadelphia Phillies) and another team six games over .500 and in the hunt for a playoff spot in the National League (the St. Louis Cardinals).

Meanwhile, the Twins are 2-7 in Chris Paddack’s last nine starts, and his ERA has ballooned from 3.53 to 4.64 amid a poor stretch of five outings. History is also on Chicago’s side after not being swept in any of its 14 road series this season.

With Twins slugger Byron Buxton day-to-day after leaving last night’s game with an injury, it makes sense that all the best sports betting sites took these moneyline odds overnight from -110 on each side to as high as the Cubs being -131 betting favorites at DraftKings. I'm backing this line movement and am making a play on Chicago’s moneyline odds as my Cubs vs. Twins best bet.

💰 Best Cubs vs. Twins player props

✅ Best Cubs vs. Twins player prop: Harrison Bader to hit a home run (+750 via DraftKings)

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Harrison Bader has hit four home runs in the last five Twins home games after swatting just two dingers over the team’s first 36 home contests. He's likely to get at least two at-bats against Rea, who has allowed one home or more run in 10 of his last 12 starts, and five combined in his last three outings.

I wanted to go the safer route with the Over on Bader’s RBIs (the best odds is at Caesars, which offers +227). But considering Bader hasn't driven in a run in a game without homering since June 1, his odds to go yard are a much better value and would return a nice payout as our best Cubs vs. Twins player prop.

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❓MLB betting FAQs

How do betting odds work?

Betting odds represent the probability of a specific outcome and determine how much money you can win on a bet. There are three main formats: American odds, Decimal odds, and Fractional odds. In the U.S., American odds are most common.

What is the run line in baseball?

The run line in baseball is a form of point spread betting unique to MLB. It typically sets a standard spread of 1.5 runs, meaning the favored team must win by at least two runs to cover the run line, while the underdog can lose by one run or win outright to cover.

What does moneyline mean in betting?

The moneyline in betting refers to a wager on which team or player will win the game outright, with no point spread involved. It’s the most straightforward type of sports bet—just pick the winner.

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Written by:
Mike Spector

Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”