Diamondbacks vs. Padres Prediction, Odds & Best Bets: Will Arraez Help Padres Salvage Series Split?

Expect a big game from Arraez tonight - we have him collecting a couple of hits against Rodriguez.

Mike Spector

Last Updated: July 10, 2025 10:05 AM EDT • 4 minute read

Diamondbacks vs. Padres prediction for Thursday, July 10 — Pictured: Luis Arraez - who's highlighted in our best Diamondbacks vs. Padres prediction - is congratulated by Fernando Tatis Jr. after hitting a solo home run. Photo by: Denis Poroy-Imagn Images

Our Diamondbacks vs. Padres prediction rounds out Thursday’s Major League Baseball coverage, with first pitch flying at 9:40 p.m. ET from Petco Park in San Diego (MLBN). Arizona has won two of the first three games of this series and is now a -120 moneyline road favorite as we make our Diamondbacks vs. Padres best bets.

Arizona’s pitching has allowed an average of just two runs per game in this series, but we expect a San Diego slugger to have a big day.

Diamondbacks vs. Padres prediction: Padres to win (+108 via FanDuel) ⭐⭐⭐
Best Diamondbacks vs. Padres player props: Luis Arraez to record 2+ hits (+185 via FanDuel) ⭐⭐⭐⭐

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✅ Diamondbacks vs. Padres prediction: Padres to win (+108 via FanDuel)

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San Diego has done well to avoid losing streaks at Petco Park of late, going 9-0 in its last nine home games against National League opponents following a loss. And it is also a profitable 4-4 as home underdogs this season, which is why I am backing it as my Diamondbacks vs. Padres prediction.

San Diego has the worst record against teams over .500 among non-last place teams in the NL. But it has handled teams with losing records well, going 33-13 in such games.

Arizona is also 5-9 in Eduardo Rodriguez’s last 14 starts, so there is plenty of value in San Diego’s +108 moneyline odds at FanDuel (the next closest odds are +101 at DraftKings) as our Diamondbacks vs. Padres best bet. While we expect the game to start off slow, as you'll see in our best NRFI bets today, expect San Diego to come to play tonight.

💰 Best Diamondbacks vs. Padres player props

✅ Best Diamondbacks vs. Padres player prop: Luis Arraez to record two or more hits (+185 via FanDuel)

Prior to yesterday’s 0-for-4 day, Luis Arraez had batted .336 in his last 26 games. That was a marked improvement from his .245 average in the prior 27 games.

Arraez has only gone hitless in consecutive games twice since May 26, and he followed up his last hitless game with a multi-hit performance in a win on July 4.

Arraez now faces Rodriguez, whose OBA to left-handed batters (.352) is 61 points higher than what he allows to righties (.291). Thus, Arraez to record two or more hits is our best Diamondbacks vs. Padres player prop. The best value is through FanDuel’s +185 odds, compared to bet365’s +165 odds on the low end of the market.

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Written by:
Mike Spector

Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”