Guardians vs. Astros Prediction, Odds & Best Bets: Back Houston to Stay Hot Today

This is a story of two teams heading in opposite directions.

Cleveland's offense is in a massive tailspin, as the team's bats have scored more than two runs just once across the last seven games. Meanwhile, Houston is coming off a sweep of the World Series odds leading Los Angeles Dodgers. As a result, we're riding them as part of our best Guardians vs. Astros prediction. 

We've got more plays for you, too, so let's dive into our Guardians vs. Astros best bets, with first pitch flying at 8:10 p.m. ET from Daikin Park.

• Guardians vs. Astros prediction: Astros to win (-135 via bet365) ⭐⭐⭐⭐⭐
• Best Guardians vs. Astros player props: Yainer Diaz Over 1.5 bases (+130 via FanDuel) ⭐⭐⭐⭐⭐

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💰 Guardians vs. Astros prediction & best bet

✅ Guardians vs. Astros prediction: Astros ML (-135 via bet365)

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We've teased this already, but our best Guardians vs. Astros prediction has to be Houston on the moneyline. I'd typically price this closer to -160 than -135 due to just how historically bad this Cleveland offense has been.

It's not even funny anymore, as this team simply can't hit right now. This specific pitching matchup also works in our favor, as the Astros have historically been successful against Tanner Bibee over his career.

Houston owns a .310 xBA over 27 plate appearacnes against him, and the team is striking out at just an 11% clip. The Astros are just rolling right now after winning 11 of their last 13 games, including sweeps of the Phillies and Dodgers. We're riding them one more time as part of our Guardians vs. Astros best bets.

💰 Best Guardians vs. Astros player props

✅ Best Guardians vs. Astros player prop: Yainer Diaz Over 1.5 bases (+130 via FanDuel)

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Remember when we said the Astros like what they see from Bibee? Well, Diaz has been leading the charge on that front.

While it's a small sample size, Diaz is 3-for-5 against Bibee in his career, and he should be able to get the job done for us. He's currently riding a five-game hitting streak, too, including back-to-back games with a home run, and a multi-hit game against the Dodgers just yesterday.

This is a sneaky good play, with value too. I'd price this closer to +115, so it's a must-bet for me at +130. Let's ride Diaz together as part of our best Guardians vs. Astros player props.

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❓MLB betting FAQs

How do betting odds work?

Betting odds represent the probability of a specific outcome and determine how much money you can win on a bet. There are three main formats: American odds, Decimal odds, and Fractional odds. In the U.S., American odds are most common. 

What is the run line in baseball?

The run line in baseball is a form of point spread betting unique to MLB. It typically sets a standard spread of 1.5 runs, meaning the favored team must win by at least two runs to cover the run line, while the underdog can lose by one run or win outright to cover.

What does moneyline mean in betting?

The moneyline in betting refers to a wager on which team or player will win the game outright, with no point spread involved. It’s the most straightforward type of sports bet—just pick the winner.

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