Guardians vs. Astros Prediction, Odds & Best Bets: Brown Set to Continue Cleveland's spiral

Last Updated: July 8, 2025 3:19 PM EDT • 4 minute read X Social Google News Link

Two teams can't get further in opposing directions as we make our Guardians vs. Astros prediction.
A once-promising season for Cleveland needs to be resurrected soon, as the Guardians have lost 10 of their last 11 games. They stopped a lengthy slide while winning the series opener against the Houston Astros 7-5 last night. But the AL West-leading Astros have still taken 11 of their previous 15 outings, propelling themselves to fifth in the World Series odds.
The Astros are the heavily favored side at our best MLB betting sites as we look at our Guardians vs. Astros best bets ahead of first pitch at 8:10 p.m. ET from Daikin Park.
- Guardians vs. Astros prediction: Astros to win (-200 via FanDuel) ⭐⭐⭐⭐
- Best Guardians vs. Astros player props: Hunter Brown Over 6.5 strikeouts (-140 via FanDuel) ⭐⭐⭐⭐⭐
⚾ Guardians vs. Astros prediction & odds
🔎 Our NEW MLB player prop odds tool can help you find the best MLB odds to make your best MLB picks.
📊 Live Guardians vs. Astros odds
💰 Guardians vs. Astros prediction & best bet
✅ Guardians vs. Astros prediction: Astros to win (-200 via FanDuel)
Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.
The Guardians' offense simply can't be trusted in any matchup right now, let alone a time when they'll be spending much of the evening opposing the flamethrowing Hunter Brown and his 126 strikeouts (sixth in MLB) and 1.82 ERA (first).
Cleveland sits a putrid 27th in scoring as we make our Guardians vs. Astros prediction, a near-basement residency that's been reached largely through their latest stumbling around. Scoring has been a blue-moon-like occurrence over their last 11 games, a span during which the Guardians have tallied two or fewer runs eight times. Worse, that stretch also includes five shutouts.
An offense terrified of scoring is facing a hurler who has incredibly posted six shutouts across his 17 starts, and Hunter has given up three-plus runs just twice over 104 innings.
The value might not be overly appealing for this Guardians vs. Astros best bet, but the choice is clear.

💰 Best Guardians vs. Astros player props
✅ Best Guardians vs. Astros player prop: Hunter Brown Over 6.5 strikeouts (-140 via FanDuel)
Much like the prop pick in our Dodgers vs. Brewers prediction today, this is another case of modest yet still alluring value considering the matchup for one of our best Guardians vs. Astros player props.
Brown, who sits far behind Tarik Skubal but is a Cy Young odds contender nonetheless, is getting prices as short as -155 from some of our best sports betting sites to go Over 6.5 strikeouts, including BetMGM and DraftKings. That leads to an implied probability of 60.8%, while the -140 through FanDuel translates to 58.3%, giving you a fine opportunity to use a FanDuel promo code.
The shorter prices are more in line with projections that list him as high as 7.42 strikeouts for tonight.
The Guardians' ineptitude sometimes doesn't extend to strikeouts, a category in which they sit mid-pack leaguewide. However, it's tough to find punchout peers for Brown with his 10.9 K/9 that ranks sixth in MLB. A fine one is Skubal, whose 11.5 K/9 is tied for the MLB lead, and just two days ago he struck out 10 Guardians batters while allowing a mere three hits and no runs over seven innings.
💡 More MLB predictions today
- MLB home run predictions
- Best NRFI Bets Today
- Rays vs. Tigers prediction
- Mariners vs. Yankees prediction
- Dodgers vs. Brewers prediction
- Guardians vs. Astros prediction
❓MLB betting FAQs
How do betting odds work?
Betting odds represent the probability of a specific outcome and determine how much money you can win on a bet. There are three main formats: American odds, Decimal odds, and Fractional odds. In the U.S., American odds are most common.
What is the run line in baseball?
The run line in baseball is a form of point spread betting unique to MLB. It typically sets a standard spread of 1.5 runs, meaning the favored team must win by at least two runs to cover the run line, while the underdog can lose by one run or win outright to cover.
What does moneyline mean in betting?
The moneyline in betting refers to a wager on which team or player will win the game outright, with no point spread involved. It’s the most straightforward type of sports bet—just pick the winner.
💵 Best MLB betting sites
Want to bet on Guardians vs. Astros? Check out the best MLB betting sites and best sportsbook promos for today's MLB games:
- FanDuel Promo Code | Read our FanDuel Review
- DraftKings Promo Code | Read our DraftKings Review
- Hard Rock Bet Promo Code | Read our Hard Rock Bet Review
(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.
Not intended for use in MA.
Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

Sean Tomlinson X social