Oregon State vs. Louisville Predictions, Odds & Best Bet: Who'll Win in Omaha?

Louisville and Oregon State will fight to keep their seasons alive in Omaha. Which powerhouse will advance to take on Coastal Carolina?

Gabe Henderson

Last Updated: June 16, 2025 11:47 PM EDT • 3 minute read

Oregon State vs. Louisville Predictions & Odds: College World Series Best Bet — Pictured: Oregon State Beavers left fielder Gavin Turley (1) rounds third after hitting a solo home run against the Coastal Carolina Chanticleers. Photo by Dylan Widger via Imagn Images.

The Louisville Cardinals and Oregon State Beavers look to keep their respective seasons alive when they meet in an elimination game this afternoon. Our Oregon State vs. Louisville prediction and odds highlight the latest betting lines and best bets for the College World Series contest.

First pitch is set for 2 p.m. ET (ESPN) from Charles Schwab Field in Omaha, Neb., with our best sports betting sites listing the Beavers as significant moneyline favorites.

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✅ Oregon State vs. Louisville prediction: Louisville (+165 via Caesars) ⭐⭐⭐
✅ Over/Under prediction: Under 10.5 runs (-113 via FanDuel) ⭐⭐⭐⭐

🆚 Who will win Oregon State vs. Louisville?

Oregon State got the better of Louisville in the opening game of the tournament, walking off the Cardinals to move into the winner's bracket. However, it's the ACC representative who played better baseball in response, and it continues to show the resiliency that got it to Omaha in the first place.

The Beavers are in a better spot with a plethora of fresh arms in the bullpen, such as former Friday night starter Nelson Keljo. However, with the momentum favoring the hosts, we cannot in good faith recommend backing Oregon State (-195). Thus, we'll take a flier on the composed Cardinals (+165) at our best sports betting apps.

✅ Moneyline pick: Louisville will win (+165 via Caesars)

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💰 Oregon State vs. Louisville best bet

Here is my best bet for today's Oregon State vs. Louisville matchup:

📉 Under 10.5 runs

Best odds: -113 via FanDuel (bet $10 to win $8.85 profit)
Implied win probability: 53.05%

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These teams are neck-and-neck in many statistical categories, meaning there isn't much to separate them. We saw as much in their opening games in Omaha.

The one similarity they share is a tendency to go Under in the postseason, as they focus on doing the little things right on the diamond, which plays well at "The Chuck."

The Beavers have gone Under in seven of their 10 postseason games, whereas the Cardinals' games have seen fewer than 11 runs scored five times in eight tries. There's a lot of uncertainty regarding the starters, which has led to an inflated total. We'll ride the trends, even at FanDuel's slightly higher than average juice (-113).

⚾ Oregon State vs. Louisville odds today

Here are the live odds for today's Oregon State vs. Louisville matchup. See all of today's college baseball odds for the latest lines from our best baseball betting sites.

💵 Best college baseball betting sites

Want to bet on Oregon State vs. Louisville? Check out the best baseball betting sites and best sportsbook promos for today's College World Series games:

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Written by:
Gabe Henderson

Gabe Henderson is a sports betting writer from Houston, Texas. He graduated from Louisiana State University in 2022 with a bachelor's degree in Mass Communication. Gabe developed an interest in sports betting while in college due to its legalization in Louisiana. He turned his passion into a career shortly after, joining The Advocate/NOLA.com as a Sports Betting Content Coordinator, where he spent two years. Gabe wore many hats before graduating as he led FanSided's coverage of Chelsea FC as a Site Expert with "The Pride of London." He was also the Editor-in-Chief of the LSU Gumbo Yearbook for two years. Gabe became a part of the SportsbookReview.com team in late 2024. He brings with him an extensive knowledge of many sports, including — but not limited to — NFL, NCAA, MLB, NBA, soccer, and UFC.