Padres vs. Dodgers Predictions, Odds & Best Bet: Who'll Win Tonight?

Shohei Ohtani is back on the mound, and he's the focus of our best bet for the NL West clash tonight.

Last updated: June 16, 2025 8:46 PM EDT • 3 min read

Padres vs. Dodgers Predictions, Odds & Best Bet: Monday, June 16 — Pictured: Los Angeles Dodgers designated hitter Shohei Ohtani (17) taks to San Diego Padres catcher Martin Maldonado (15). Photo by David Frerker / Imagn Images.

Shohei Ohtani makes his return to the mound today at Dodger Stadium (10:10 p.m. ET, SDPA), as we offer our best Padres vs. Dodgers prediction and odds - including our best Ohtani prop bet ahead of his pitching debut.

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✅ Padres vs. Dodgers prediction: Padres (+132 via FanDuel) ⭐⭐⭐
✅ Over/Under prediction: Under 9 (-115 via BetMGM) ⭐⭐
✅ Best player prop pick: Shohei Ohtani Over 1.5 strikeouts (+120 via Caesars) ⭐⭐⭐⭐

🆚 Who will win Padres vs. Dodgers?

The Dodgers took two of three contests when these teams met last week, but the Padres scored their lone win behind a 7-inning gem from Dylan Cease (2-5, 4.28 ERA), whose surface stats simply don't tell the full story for the two-time Cy Young finalist.

The prop market is projecting a shortened stint for Ohtani - and our best NRFI bets expect a strong start - but the full-game market seems to be dismissing the cost of downgrading to a beleaguered bullpen after the first few innings. That's why I love this plus-money price on San Diego.

✅ Moneyline pick: Padres will win (+132 via FanDuel)

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💰 Padres vs. Dodgers best bet

Here is my best bet for today's Padres vs. Dodgers matchup:

💪 Shohei Ohtani Over 1.5 strikeouts

Best odds: +120 via Caesars ($10 pays $12)
Implied win probability: 45.45%

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Ohtani is only expected to toss one or two innings in his first trip to the mound in nearly two years. That's all he'll need to cash this prop if he looks anything like he did in his rehab work last week.

Ohtani struck out six across three simulated innings in those 44 pitches, and he punched out 11.4 batters per nine innings in his last season as a pitcher in 2023. He has a real shot to cash this one in just one inning of work - if he gets a second, I love our chances to profit on these plus-money odds via Caesars.

Our Dustin Saracini breaks down even further why this is such a great value in his best Shohei Ohtani player prop picks. While +120 is a clear outlier on the market, I'd still play this down to +105, which are currently the market-worst odds offered by DraftKings.

⚾ Padres vs. Dodgers odds today

Here are the live odds for today's Padres vs. Dodgers matchup. See all of today's MLB odds for the latest lines from our best MLB betting sites.

💰 Latest Padres vs. Dodgers odds & betting lines

Here are the latest odds and betting insights via BetMGM for tonight's game:

The Dodgers remain -160 favorites with roughly an hour until first pitch, and 82% of all moneyline bets have been placed on favorite Los Angeles
Bettors are expecting a low-scoring affair with 57% of bets coming on Under 9, which is juiced to -115 odds

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Written By:
C Jackson Cowart

C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.