Padres vs. Dodgers Predictions, Odds & Best Bet: Who'll Win Tonight?

Last updated: June 16, 2025 8:46 PM EDT • 3 min read X Social Google News Link

Shohei Ohtani makes his return to the mound today at Dodger Stadium (10:10 p.m. ET, SDPA), as we offer our best Padres vs. Dodgers prediction and odds - including our best Ohtani prop bet ahead of his pitching debut.
🔮 Padres vs. Dodgers prediction & picks
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✅ Padres vs. Dodgers prediction: Padres (+132 via FanDuel) ⭐⭐⭐
✅ Over/Under prediction: Under 9 (-115 via BetMGM) ⭐⭐
✅ Best player prop pick: Shohei Ohtani Over 1.5 strikeouts (+120 via Caesars) ⭐⭐⭐⭐
🆚 Who will win Padres vs. Dodgers?
The Dodgers took two of three contests when these teams met last week, but the Padres scored their lone win behind a 7-inning gem from Dylan Cease (2-5, 4.28 ERA), whose surface stats simply don't tell the full story for the two-time Cy Young finalist.
The prop market is projecting a shortened stint for Ohtani - and our best NRFI bets expect a strong start - but the full-game market seems to be dismissing the cost of downgrading to a beleaguered bullpen after the first few innings. That's why I love this plus-money price on San Diego.
✅ Moneyline pick: Padres will win (+132 via FanDuel)
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💰 Padres vs. Dodgers best bet
Here is my best bet for today's Padres vs. Dodgers matchup:
💪 Shohei Ohtani Over 1.5 strikeouts
- Best odds: +120 via Caesars ($10 pays $12)
- Implied win probability: 45.45%
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Ohtani is only expected to toss one or two innings in his first trip to the mound in nearly two years. That's all he'll need to cash this prop if he looks anything like he did in his rehab work last week.
Ohtani struck out six across three simulated innings in those 44 pitches, and he punched out 11.4 batters per nine innings in his last season as a pitcher in 2023. He has a real shot to cash this one in just one inning of work - if he gets a second, I love our chances to profit on these plus-money odds via Caesars.
Our Dustin Saracini breaks down even further why this is such a great value in his best Shohei Ohtani player prop picks. While +120 is a clear outlier on the market, I'd still play this down to +105, which are currently the market-worst odds offered by DraftKings.
⚾ Padres vs. Dodgers odds today
Here are the live odds for today's Padres vs. Dodgers matchup. See all of today's MLB odds for the latest lines from our best MLB betting sites.
💰 Latest Padres vs. Dodgers odds & betting lines
Here are the latest odds and betting insights via BetMGM for tonight's game:
- The Dodgers remain -160 favorites with roughly an hour until first pitch, and 82% of all moneyline bets have been placed on favorite Los Angeles
- Bettors are expecting a low-scoring affair with 57% of bets coming on Under 9, which is juiced to -115 odds
💡 More MLB predictions today
- Best NRFI bets today
- Home run predictions
- Shohei Ohtani player props
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- Padres vs. Dodgers predictions
💵 Best MLB betting sites
Want to bet on Padres vs. Dodgers? Check out the best MLB betting sites and best sportsbook promos for today's MLB games:
- FanDuel Promo Code | Read our FanDuel Review
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- Hard Rock Bet Promo Code | Read our Hard Rock Bet Review
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