Red Sox vs. Mariners Predictions, Odds & Best Bet: Who'll Win Tonight?

Do the Red Sox have enough on offense to beat the Mariners after trading Rafael Devers to the Giants?

Rob Paul

Last updated: June 16, 2025 8:51 PM EDT • 3 min read

Red Sox vs. Mariners Predictions, Odds & Best Bet — Pictured: Seattle Mariners centerfielder Julio Rodriguez hits a single against the Baltimore Orioles. Photo by Stephen Brashear via Imagn Images.

The Boston Red Sox look to keep their fans' hopes up after trading Rafael Devers as they hit the West Coast tonight to take on the Seattle Mariners at 9:40 p.m. ET (Fubo) from T-Mobile Park in Seattle. Our Red Sox vs. Mariners prediction and odds expect Julio Rodriguez to lead Seattle to victory.

🔮 Red Sox vs. Mariners prediction & picks

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✅ Red Sox vs. Mariners prediction: Mariners (-169 via BetRivers) ⭐⭐⭐
✅ Over/Under prediction: Over 7 (-120 via Caesars) ⭐⭐⭐⭐⭐
✅ Best player prop pick: Julio Rodriguez Over 1.5 total bases (+115 via Caesars) ⭐⭐⭐⭐

🆚 Who will win Red Sox vs. Mariners?

Boston fans are reeling after Devers was traded to the San Francisco Giants, seemingly ending the Red Sox's shot at making a playoff push. With their World Series odds sunk, flying across the country to Seattle to take on a Mariners team that just swept the Cleveland Guardians is a tall task. Boston is set to march Lucas Giolito out to the mound, and the struggling 30-year-old could be in for a long night against a surging Rodriguez.

✅ Moneyline pick: Mariners will win (-169 via BetRivers)

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💰 Red Sox vs. Mariners best bet

Here is my best bet for today's Red Sox vs. Mariners matchup:

⚓ Julio Rodriguez Over 1.5 total bases

Best odds: +115 via Caesars ($10 pays $11.50)
Implied win probability: 46.51%

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Rodriguez has been red hot lately, slashing .370/.393/.481 over his last six games with 13 total bases. And the two-time All-Star has recorded two-plus hits in nine of his last 15 games, including four of his last six.

Giolito is the perfect pitcher matchup for Rodriguez to continue mashing, with the Red Sox righty holding an ugly 5.45 ERA that includes allowing 16 earned runs and 25 hits across his last four starts (20 1/3 innings). The Red Sox righty also frequently uses his four-seamer (47% of the time), a pitch against which Rodriguez has a .607 xSLG and a 57.8% hard-hit rate, per Baseball Savant.

⚾ Red Sox vs. Mariners odds today

Here are the live odds for today's Red Sox vs. Mariners matchup. See all of today's MLB odds for the latest lines from our best MLB betting sites.

💰 Latest Red Sox vs. Mariners odds & betting lines

Here are the latest odds and betting insights via BetMGM for tonight's game:

The Mariners are -175 favorites to beat the Red Sox in their first game since trading away Rafael Devers, with 75% of bets coming on Seattle
While this O/U of 7 runs is one of the lowest of the week, bettors aren't buying it with 76% of bets coming on the Over

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Written By:
Rob Paul

Rob is a Publishing Editor at Sportsbook Review. He’s been with the team since early 2024, with this being his first full-time role in the sports betting industry. Before joining SportsbookReview.com, he contributed to various sports outlets, including FanSided and Pro Football Network. During that period, he spent five years working full-time as a local community journalist, after attending Durham College for journalism and Wilfrid Laurier University for history. He previously hosted an NFL draft and college football-focused podcast where he had the opportunity to interact with future NFL players such as Maxx Crosby and Quinn Meinerz. Rob has spent multiple years working as a freelance podcast producer for numerous sports-related podcasts while making guest appearances on several college football shows. He’s also made guest appearances on SportsTalk Mississippi on several occasions to talk all things NFL draft. Rob values the way sports betting acts as a catalyst for telling stories and growing interest in certain sports, particularly FCS football, WNBA, and mid-major college basketball. He’s always been drawn to the more obscure teams and conferences in major college sports, but most of all, Rob loves using stats to find the best player props to back.