Oleksandr Usyk vs. Daniel Dubois 2 Prediction, Expert Picks & Odds: Heavyweight

Oleksandr Usyk is a sizable -334 favorite against Daniel Dubois tonight - will we see a upset?

Last Updated: July 19, 2025 3:05 PM EDT • 4 minute read

Oleksandr Usyk vs. Daniel Dubois 2 Prediction, Expert Picks & Odds — Pictured: Oleksandr Usyk - who's highlighted in our Usyk vs. Dubois prediction - after a win. Photo by: Jon Durr-Imagn Images

Will there be an upset tonight when it comes to my full Oleksandr Usyk vs. Daniel Dubois predictions and expert picks?

Usyk will defend his unified heavyweight titles on Saturday, July 19, when he meets Dubois for a second time at Wembley Stadium in London. Usyk won their first fight by knockout in 2023 and now looks to cement his reign with another decisive performance. Despite Dubois’ punching power, Usyk enters as a solid -334 favorite.

The top sportsbooks all have Usyk vs. Dubois odds, with Usyk a consensus favorite across the board.

📊 Oleksandr Usyk vs. Daniel Dubois odds

Odds via bet365 as of Friday

Oleksandr Usyk	Method of Victory	Daniel Dubois
-334	Win outright	+250
+125	Win by KO/TKO/DQ	+400
+175	Win by decision	+1100
+1600	Draw	+1600

Usyk’s -334 betting odds mean a $100 bet would pay about $30 in profit. Meanwhile, a $100 wager on Dubois would net $250 if the underdog pulls off the upset.

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🥊 Oleksandr Usyk vs. Daniel Dubois prediction & fight preview

✅ Prediction: Oleksandr Usyk to beat Daniel Dubois
📊 Best odds: -334 via bet365 ($10 → $12.99)

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Usyk is one of boxing’s most skilled heavyweights, with elite footwork, defensive craft, and shot selection that frustrates even the biggest punchers. In their first bout, Dubois had some moments but was ultimately broken down and stopped in Round 9.

Given Dubois’ danger, expect Usyk to stay busy and look to wear him out again. Hanging around too long is risky against a puncher like Dubois, so the smart move for Usyk may be to force the pace in the mid rounds.

For Dubois, it’s all about landing a bomb. He’s got genuine power, but questions about his chin and ability to handle extended damage over 12 rounds linger. If he can’t catch Usyk early, the champ’s class should shine through. I'm riding with him as part of my Usyk vs. Dubois predictions.

💰 Oleksandr Usyk vs. Daniel Dubois best bet

✅ Best bet: Usyk by KO/TKO (+100)
📊 Best odds: +125 via Bet365 ($10 → $25)

Usyk by stoppage makes the most sense. While he could box safely to a decision, there’s little incentive to hang around with Dubois’ power for 12 rounds. Expect Usyk to turn up the heat once Dubois slows, forcing another stoppage. At +125, the KO/TKO prop presents a ton of value and is my Usyk vs. Dubois best bet.

If you’re hunting extra payout, look for group rounds around 5-8 to mirror how the first fight closed.

🆚 Oleksandr Usyk vs. Daniel Dubois tale of the tape

Daniel Dubois	Attribute	Oleksandr Usyk
27	Age	38
6-foot-5	Height	6-foot-3
240 pounds	Weight	220 pounds
78 inches	Reach	78 inches
20-2 (19 KOs), heavy puncher	Record	22-0 (14 KOs), unified HW champ

📡 How to watch Oleksandr Usyk vs. Daniel Dubois

📅 Saturday, July 19, 2025
🕗 Approx. 5 p.m. ET main event ringwalks
📍 Wembley Stadium, London, England
📺 Streaming live on DAZN Pay-Per-View

❓ Usyk vs. Dubois FAQs

Who is favored to win the Usyk vs. Dubois fight?

Oleksandr Usyk is the -334 favorite, while Daniel Dubois sits as a +250 underdog.

How do boxing odds work?

Minus odds (like -334) show how much you’d bet to win $100, while plus odds (like +250) show how much profit you’d earn on a $100 bet.

Who will win between Usyk vs. Dubois?

My pick: Usyk to stop Dubois by KO/TKO and retain his heavyweight titles.

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Written by:
Ethan Diamandas

Ethan Diamandas is a contributor to Sportsbook Review with over five years of experience in the sports and gaming industry. A graduate of Carleton University’s journalism program in Ottawa, Ethan has worked as both a traditional beat reporter and a feature writer covering the Toronto Blue Jays, while also diving deep into the betting side of MLB, boxing, and UFC. His bylines can be found in Sports Illustrated, MLB.com, and Yahoo Sports, among others. Ethan lives for UFC pay-per-views, whether it’s cooking up a prelim parlay or tossing a few units on a main-event underdog. While bet365 is his usual go-to for its prop selection, he shops around at FanDuel, BetMGM, and other top books to lock in the best value. Ethan believes the key to betting success is doing your research, staying patient, and only wagering on markets you truly understand. The off-the-cuff five-leg parlay looks fun but seldom pays off. Above all, his goal is to entertain and inform readers by blending sharp insights with a passion for the game.