Best Knicks vs. Lakers Odds Tonight: NBA Player Props & Score Predictions for March 6

The Los Angeles Lakers look to make it eight consecutive wins tonight when they host the New York Knicks. Tipoff is set for 10 p.m. ET (TNT) from Crypto.com Arena in Los Angeles.
Our Knicks vs. Lakers prediction and player props expect Los Angeles' superstars to shine and carry them to victory. Our best sports betting sites list the hosts as 2.5-point favorites.
The Lakers have played incredibly well since the All-Star break, winning seven straight and sporting an 11.1 net rating. But the home team will have its hands full tonight when it hosts the Eastern Conference heavyweight Knicks.
💰 Best Knicks vs. Lakers predictions & NBA player props tonight: March 6
Here are my best Knicks vs. Lakers predictions and player props for tonight's NBA matchup with my pick confidence based on a 1-to-5-star scale. Be sure to check out the rest of our NBA picks along with our guide on how to bet on the NBA.
- Game pick: Lakers to cover -4.5 (-105 via BetMGM) ⭐⭐⭐
- LeBron James player prop pick: Over 25.5 points (-108 via FanDuel) ⭐⭐⭐⭐
- Karl-Anthony Towns player prop pick: Over 36.5 points + rebounds + assists (-125 via Caesars) ⭐⭐⭐
- Luka Doncic player prop pick: Over 44.5 points + rebounds + assists (-118 via FanDuel) ⭐⭐⭐
📊 Knicks vs. Lakers pick & odds: Who will win tonight's NBA matchup?
As of Thursday evening, the Lakers are 2.5-point favorites to beat the Knicks in tonight's NBA matchup at 10 p.m. ET from Crypto.com Arena in Los Angeles. I predict the Lakers will beat the Knicks and cover the spread.
🔢 Knicks vs. Lakers odds & betting lines
Here are the latest Knicks vs. Lakers odds and betting lines from our best live betting sites.
📈 Knicks vs. Lakers odds movement
The Knicks vs. Lakers odds have shifted in the hours leading up to tipoff. Despite Los Angeles being one of the most heavily backed teams to cover the spread tonight, DraftKings lists them as 2.5-point favorites just hours before tipoff.
The Lakers are -141 moneyline favorites over the Knicks (+133) at Crypto.com Arena. The total for tonight's game is set at O/U 231.5.
🎯 Knicks vs. Lakers score prediction: Lakers 115, Knicks 109
The Lakers have looked rejuvenated since the All-Star break, winning seven straight and doing so behind strong defensive play. Los Angeles sports the second-best defensive rating in the Association over the last seven at 106.2, and the Lakers have held opponents to a league-low 103.1 points per game.
The Knicks, however, rank 19th in defensive rating at 115.4 and have allowed the 11th-most points at 116.4. New York’s defense has been elite for most of the season, but the recent slip in that department has me backing the Lakers here. Luka Doncic looks like he’s having fun and is getting back to his old self, making the Lakers a dangerous matchup every time he takes the floor.
Los Angeles is 14-9 ATS as a home favorite, and New York is 3-4 ATS as a road underdog. I’ll take the Lakers to extend their win streak and cover in a relatively low scoring game.
I predict the Lakers will beat the Knicks by a final score of 115-109.
Best bet: Lakers -4.5 (-105 via BetMGM)
💰 Best Knicks vs. Lakers player prop bet odds & expert picks: March 6
Here are my best Knicks vs. Lakers player prop bet odds and expert picks for tonight's NBA matchup. You can also check out our NBA player prop odds tool for the latest NBA odds at the best legal sportsbooks in your region.
🏀 Best LeBron James prop pick: Over 25.5 points ⭐⭐⭐⭐
Best odds: -108 via FanDuel ($10 to win $9.26)
James is averaging just 24.9 points per game this season, but his scoring has been a tale of two segments. Over the first 41 games of the season, James averaged 23.6 points and hit the Over on this line 16 times.
Over the last 15, he’s averaged 28.5 points and hit the Over 10 times. What’s been the catalyst for James’ resurgent scoring? His impressive 15-game scoring binge started in Anthony Davis’ final game as a Laker.
Davis left that game early due to injury and was traded only days later. James has picked up the slack in his absence and kept it going with Doncic as his new running mate. The good times won’t stop tonight against a flailing Knicks defense.
📊 Best LeBron James prop bet odds
🏀 Best Karl-Anthony Towns prop pick: Over 36.5 points + rebounds + assists ⭐⭐⭐
Best odds: -125 via Caesars ($10 to win $8.00)
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Towns has failed to clear this line in three of his last four, and he’s missed two of the Knicks’ last four games due to personal reasons. He’s not dealing with an injury, and he’s expected to play tonight against the Lakers.
Towns’ recent cold streak has driven his PRA line down to a criminally-low 36.5, and we’ll scoop that up without hesitation. Towns has hit the Over on this line in 34 of 54 overall and in 20 of 28 on the road.
New York’s big man is averaging 41 PRA this season, so even a below-average showing will get him over the hump here. I’m not counting on a monster night against Los Angeles’ strong defense, but he can certainly get to 37 PRA.
📊 Best Karl-Anthony Towns prop bet odds
🏀 Best Luka Doncic prop pick: Over 44.5 points + rebounds + assists ⭐⭐⭐
Best odds: -118 via FanDuel ($10 to win $8.47)
After a couple of games to work himself back into shape and get acclimated to his new team, Doncic looks right at home in Los Angeles. He’s cooked since returning from the All-Star break, and I expect him to continue his strong play tonight.
Over his last three, Doncic has averaged a healthy 27 points, nine rebounds and 8.8 assists, good for 44.8 PRA. In that span, he hit the Over three times and posted exactly 44 PRA once more.
The Knicks have allowed the 11th-most points per game over the last seven, and New York’s defensive rating has plummeted to 19th. This is a favorable matchup for the surging Doncic in front of the home crowd.
📊 Best Luka Doncic prop bet odds
🚑 Knicks vs. Lakers injuries
Here are the latest injuries for tonight's Knicks vs. Lakers matchup, which will update in real time.
📺 How to watch Knicks vs. Lakers tonight
📅 Date: March 6, 2025
🕗 Time: 10 p.m. ET
📍 Location: Crypto.com Arena (Los Angeles)
📺 TV: TNT
💻 Streaming: Max
❓ Knicks vs. Lakers FAQs
Who is favored to win Knicks vs. Lakers?
The Knicks are -169 moneyline favorites at Caesars, which carries an implied win probability of 62.83%.
What are the odds for Knicks vs. Lakers?
The Knicks are favored by as many as 4.5 points (-105 via BetMGM), and the point total is set as high as 230 (-112 via DraftKings).
What time is Knicks vs. Lakers tonight?
Tipoff from Crypto.com Arena in Los Angeles is set for 10 p.m. ET.
How to watch Knicks vs. Lakers
The Knicks vs. Lakers game can be watched on TNT or streamed on Max.
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