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Arizona vs. Houston Prediction Tonight: Big 12 Final Best Bets, Odds & Score Picks
Pictured: Houston Cougars guard Milos Uzan (7) holds onto the ball while Arizona Wildcats guard KJ Lewis (5) attempts to take the ball away. Photo by Aryanna Frank via Imagn Images.

The Big 12 will have a new tournament winner following tonight's championship game, as Arizona and Houston each search for their first titles since joining the prestigious conference. Tipoff is set for 6 p.m. ET (ESPN) from the T-Mobile Center in Kansas City, Mo.

Our Arizona vs. Houston prediction, odds, and expert picks are backing the favorites to win in a big way. The Cougars are 6.5-point favorites at our best sports betting sites in tonight's highly-anticipated Big 12 tournament title game.

While the Wildcats (22-11) made it to the conference title during their inaugural season in the Big 12, these are uncharted waters for Houston, which captured the regular season crown. Which relative newcomer will earn a program-defining win ahead of the NCAA Tournament?

💰 Arizona vs. Houston predictions, expert picks & best bets: Big 12 Final

Here are my best Arizona vs. Houston predictions, expert picks, and best bets today for Big 12 Final with my pick confidence based on a 1-to-5-star scale. Be sure to check out the rest of our college basketball picks along with our guide on how to bet on college basketball.

👉 Check out our latest March Madness projections with our SBR Bracketology ahead of the NCAA Tournament!

🏀 Arizona vs. Houston ATS prediction & best player prop bet pick

Here's why I'm betting on Houston to cover the spread (-6.5) while targeting Milos Uzan Over 3.5 assists (-134) as my best player prop bet pick for today:

✅ Houston to cover the spread (-6.5) ⭐⭐⭐⭐

The Wildcats have now had two excellent shooting performances in as many nights during this Big 12 tourney. They went 8-for-18 (44.4%) from long range against Kansas, followed by their 8-for-16 clip against Texas Tech.

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Arizona cannot keep up this shooting pace - the Wildcats rank 240th in the nation with a 3-point clip of 32.5%. 

A matchup against Houston’s No. 2 defense is an excellent opportunity to bet on regression.

📊 Best odds: -105 via BetMGM (bet $10 to win $9.52)

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🔥 Milos Uzan Over 3.5 assists ⭐⭐⭐⭐⭐

Houston guard Milos Uzan recorded five assists in last night’s 74-54 win over BYU. He’s averaging 4.3 assists per game this season, clearing this mark in 61% of his outings in 2024-25.

Uzan registered five assists against Arizona on Feb. 15, which is closer to an accurate projection if this game ends up being faster than the Cougars usually play.

📊 Best odds: -134 via FanDuel (bet $10 to win $7.46)

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🎯 Expert Arizona vs. Houston score prediction & AI projections

🔮 Expert score prediction: Houston 75, Arizona 66
🤖 AI score prediction: Houston 71, Arizona 64

🔮 Expert score prediction: Houston 75, Arizona 66

It’s been a good idea to fade Tommy Lloyd’s Wildcats in the NCAA Tournament (1-6 ATS), but his first appearance in the Big 12 title game might be as difficult. Houston hasn’t lost since Feb. 1, whereas Arizona’s last stretch of three straight victories was over a month ago.

📊 Best odds: +17000 via DraftKings (bet $10 to win $1,700)

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🤖 AI score prediction: Houston 71, Arizona 64

(Score prediction and analysis via ChatGPT - a large language model from OpenAI. While ChatGPT is not specifically designed for predicting sporting events, it can spot trends or insights that bettors might overlook.)

🖥️ AI predictions for Arizona vs. Houston

The projected final score is Houston 71, Arizona 64.

  • Win probability: Houston 70% | Arizona%
  • Projected total points: 135
  • Key takeaways:
    • Houston boasts the nation’s top-ranked defense, allowing just 58.3 points per game
    • Milos Uzan scored 19 points in the last meeting with Arizona
    • Caleb Love, who led the Wildcats with 27 points in the semifinals, will need another big performance to give his team a chance

🤔 Betting takeaway: ChatGPT's AI score prediction leans toward Houston covering the spread (-6.5) and a total of Under 135.5 points.

📊 Live Arizona vs. Houston odds & latest betting splits

Here are the latest odds for Arizona vs. Houston, which update live in real time. You can also check out our NEW college basketball player prop odds tool for the latest college basketball odds on any market across legal sportsbooks in your region.

Two of the three game line markets are incredibly lopsided in the hours leading up to tipoff in tonight's Big 12 tournament championship. Houston moneyline and the Over are receiving a majority of bets, but the spread is another story.

The Cougars are wavering between 5.5 and 6.5-point favorites with the handle almost at a 50/50 split with our best live betting sites.

🔢 Arizona vs. Houston opening odds

Here's a look at the opening odds for Arizona vs. Houston according to DraftKings.

  • Spread: Arizona +6.5 (-110) | Houston -6.5 (-110)
  • Moneyline: Arizona +225 | Houston -278
  • Over/Under: Over 135.5 (-105) | Under 135.5 (-115)

🏆 Who will win Arizona vs. Houston?

As of 3:30 p.m., Houston is favored by 6.5 points to beat Arizona with moneyline odds of -275 at BetMGM, which suggests a 73.33% win probability for the Cougars. We're predicting a 75-66 win for Houston as our final score projection.

So far, 53% of bettors have wagered against the spread on Houston -6.5, while 65% of bettors are leaning Over for the projected total of 137.5 points.

📺 How to watch Arizona vs. Houston tonight

📅 Date: Saturday, March 15
🕗 Time: 6 p.m. ET
📍 Location: T-Mobile Center (Kansas City)
📺 TV: ESPN
💻 Streaming: ESPN+

❓ Arizona vs. Houston FAQs

Who's favored to win the Big 12 tournament?

Houston is favored to win the Big 12 tournament.

Who is favored to win Arizona vs. Houston?

The Cougars are -275 to win, translating to an implied probability of 73.33%.

What are the betting odds for Arizona vs. Houston?

The latest spread is Arizona +6.5 (-118) | Houston -6.5 (-102), with a total of 137.5 points (Over -105 | Under -115).

What will be the final score of Arizona vs. Houston?

We're predicting a final score of Houston 75, Arizona 66, entering tonight's matchup at T-Mobile Center.

What time is Arizona vs. Houston tonight?

Tipoff for Arizona vs. Houston tonight is at 6 p.m. ET.

⛹️ Best college basketball betting sites

Looking to bet on college basketball tonight? Here are our best March Madness betting sites as determined by our expert team at Sportsbook Review, along with our best March Madness betting promos ahead of the NCAA Tournament.

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