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Auburn vs. Creighton Prediction, Odds & Tonight's Preview Today: March Madness Best Bets
Pictured: Auburn Tigers forward Johni Broome (4) passes the ball. Photo by Jordan Prather-Imagn Images.

The No. 1 seed Auburn Tigers (29-5) meet the No. 9 seed Creighton Bluejays (25-10) tonight at 7:10 p.m. ET (truTV) in NCAA Tournament second-round play at Rupp Arena in Lexington, Ky.

The Tigers are the 9 or 9.5-point betting favorites to advance in the South Region of the March Madness bracket. Auburn struggled a bit during the first round, while Creighton upset Louisville in the first game of the tournament. We dissect how much those performances mean in our Auburn vs. Creighton prediction, odds, and preview as part of our March Madness predictions.

🏀 Auburn vs. Creighton prediction & picks tonight

Here are my best Auburn vs. Creighton predictions for the second round of the NCAA Tournament; use our parlay calculator to get the best odds for any same-game parlay:

✅ Against the spread pick: Auburn -9.5 (-105 via BetMGM) vs. Creighton ⭐⭐⭐⭐
🔥 Best player prop bet: Johni Broome Over 10.5 rebounds (
+114 via FanDuel) ⭐⭐⭐⭐
🎯 Exact score prediction: Auburn 88, Creighton 73 (
+18000 via DraftKings)

👉 Want more picks? Check out our latest college basketball picks and the rest of our March Madness second-round predictions.

🏆 Best Auburn vs. Creighton pick, player prop bet & score prediction

Our NEW college basketball player prop odds tool can help you find the best odds for any March Madness market across legal sportsbooks in your area!

✅ Auburn to cover the spread: -9.5 ⭐⭐⭐⭐

With 1:34 remaining in the first half, the Tigers led their first-round game against the Alabama State Hornets 32-31. From that point on, they outscored the Hornets 51-32.

The lackluster start for the No. 1 overall seed has made the betting public nervous, as 72% of bettors are backing the Bluejays against the spread. However, the spread has been growing from 8.5 to 9.5 at most of our best sportsbooks, which means oddsmakers aren’t trying to offset the public action.

The Bluejays dominated the Louisville Cardinals in the first round, as Jamiya Neal scored 29 points while pulling down 12 rebounds. As a team, they shot 57.1% from the field and 45.8% from 3-point range. However, the Bluejays are running into a very different squad on Saturday.

Though the Cardinals and Tigers allowed nearly identical points per game this season, the Tigers gave up just 69.4 points per game despite playing 21 Quad 1 contests. The Cardinals played only 11.

The Tigers needed a half to get comfortable. Now they’re going to shut down the Bluejays’ offense and win their 22nd game of the year by double figures.

📊 Best odds: -105 via BetMGM ($10 to win $9.52)

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🔥 Johni Broome Over 10.5 rebounds ⭐⭐⭐⭐⭐

The 7-foot-11 Ryan Kalkbrenner causes matchup problems for most teams. But between Broome, one of the leader contenders in the Wooden Award odds, and Dylan Cardwell, the Tigers hold the advantage down low. And although the Bluejays boast the 34th-best shooting percentage in the nation, the Tigers will dominate the glass, as Creighton ranks 164th in rebounds allowed per game.

Broome enters this matchup averaging 10.6 rebounds per game, which is eighth-best in the nation. Though he only pulled down 11 boards in the first round, he also played just 27 minutes. It was the first time he played fewer than 30 minutes in a game since Feb. 4. 

Broome will play more minutes on Saturday, which puts his rebounding floor at seven boards based on his play throughout the season. After Thursday’s performance, Broome has now logged 18 games with at least 11 rebounds. This is a must-play considering that consistency and the price of +114.

📊 Best odds: +114 via FanDuel ($10 to win $11.40)

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🎯 Exact score prediction: Auburn 88, Creighton 73

The Bluejays weren't playing well defensively before the NCAA tournament. They gave up more than 80 points in two of their final three games, and the team allowed the Butler Bulldogs and DePaul Blue Demons to shoot well, despite both teams trotting out mediocre offenses. 

Because of how the Bluejays’ defense ended the year, I expect the Tigers to score plenty in this game. They’re averaging 83.8 points per outing, and they should clear that total on Saturday. I may be underselling the Creighton offense a bit with this final score, but the Tigers’ defense could frustrate the Bluejays in a similar way to what the St. John’s Red Storm did while limiting the Bluejays to just 66 points on March 15.

📊 Best odds: +18000 via DraftKings ($10 to win $1,800)

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🤖 Auburn vs. Creighton AI prediction

For entertainment purposes, we asked ChatGPT to analyze historical trends and live NCAA Tournament stats before predicting the winner and exact score for Auburn vs. Creighton. Our AI prediction projects a final score of Auburn 75, Creighton 71.

🖥️ AI score prediction: Auburn 75, Creighton 71

  • Their key players often excel in both scoring and defending, but the Tigers’ success tends to depend on their 3-point shooting and offensive rebounding.
  • Their offense revolves around skilled shooters and ball movement, and they often play a more efficient, balanced style compared to some teams that rely on high tempo.
  • If Auburn can limit Creighton’s shooting and control the pace, that could help them secure a victory.

🤔 Betting takeaway: ChatGPT's AI prediction would mean Creighton covering the spread (+9.5) and a total of Under 151 points. ChatGPT is not a dedicated sports betting model, but it can identify data that March Madness bettors might overlook.

📊 Live Auburn vs. Creighton odds

Follow the latest live March Madness college basketball odds and real-time NCAA Tournament scores for the second round.

Latest Auburn vs. Creighton odds

Here are the latest Auburn vs. Creighton odds via BetMGM in the hours ahead of the 7:10 p.m. ET tipoff:

Spread

Auburn is an 8.5-point betting favorite with -120 odds to cover with a win by 9 or more points.

Total

The Auburn vs. Creighton Over/Under is set at 149.5 points, down a point from the opening line.

Moneyline

The -450 moneyline odds for Auburn to win outright represent an implied win probability of 82%.

🔢 Auburn vs. Creighton opening odds

  • Spread: Auburn –8.5 (-115) | Creighton +8.5 (-105)
  • Moneyline: Auburn -425 | Creighton ++325
  • Over/Under: Over 150.5 (-115) | Under 150.5 (-105)

📺 How to watch Auburn vs. Creighton: NCAA Tournament second round

📅 Date: Saturday, March 22
🕗 Time: 7:10 p.m. ET
📍 Location: Rupp Arena (Lexington, Ky.)
📺 TV: TBS, TruTV
💻 Streaming: March Madness Live, Max

🏀 Best March Madness odds, predictions & expert picks tonight

Here are our best March Madness picks for Saturday's second-round action:

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