Duke vs. Miami Prediction, Expert Picks & Odds, Feb. 25: Our Best Bets for Tonight

Our Duke vs. Miami prediction and odds back the Blue Devils to cover comfortably against a struggling Hurricanes squad sitting at the bottom of the ACC. Duke is among the top March Madness odds contenders, while Miami faces an uphill battle after a 2-14 start to conference play.
Tipoff is set for 7 p.m. ET (ESPN) from Watsco Center in Coral Gables, Fla., where Cooper Flagg is expected to shine and take advantage of the Hurricanes' lackluster perimeter defense.
Duke vs. Miami predictions, expert picks & best bets today
Here are my best Duke vs. Miami predictions, expert picks, and best bets tonight with my pick confidence based on a 1-to-5-star scale. Be sure to check out the rest of our college basketball picks along with our guide on how to bet on college basketball.
- Against the spread pick: Duke -22 (-112 via BetRivers) vs. Miami ⭐⭐⭐
- My best player prop bet: Cooper Flagg Over 1.5 made 3-pointers (+105 via BetMGM) ⭐⭐⭐⭐
Duke vs. Miami ATS pick & score prediction
With the Blue Devils playing at another level right now behind their freshman trio, and the Hurricanes being among the worst teams in the country, I'm predicting Duke will cover the spread (-22).
🏀 Duke to cover the spread: -22 ⭐⭐⭐
Since Jim Larranaga abruptly stepped down as Miami's head coach 12 games into the season with a 4-8 record, the Hurricanes have only become worse. Former Cornell bench boss and current Miami interim head coach Bill Courtney is 2-13 since taking over, and the Canes rank 335th in adjusted defensive efficiency, per KenPom.
The last time Miami played Duke it lost 89-54 as a 23.5-point underdog. I don't see any way the Hurricanes can contain the Blue Devils' scoring attack now with their defensive issues. Miami is allowing the most points per game (83.1) and the highest field-goal percentage in ACC play (50.4%).
Are the Hurricanes really going to stop the freshman trio of Flagg, Kon Knueppel, and Khaman Maluach? They combined for 50 points, 24 rebounds, and nine assists the last time Duke played Miami. And those three have the Blue Devils sitting second in the country in adjusted offensive efficiency. The team is also putting up the most points per game in the ACC (82.3), and allowing the fewest points in conference play (62.5)
Best odds: -112 via BetRivers (bet $10 to win $8.93)
🎯 Final score prediction: Duke 90, Miami 64
Duke embarrassed Miami the last time the two programs met, and the Blue Devils have only become better since then. They just handed an Illinois team projected for a top-eight seed in the NCAA Tournament, per Bracket Matrix, the worst loss in program history (43 points).
That's why I'm predicting a final score of Duke 90, Miami 64, with the Blue Devils leaning on their freshman trio alongside veterans Tyrese Proctor and Sion James.
Correct score odds: +19000 via DraftKings (bet $10 to win $1,900)
Best Duke vs. Miami player prop bet
Here is my best Duke vs. Miami player prop bet tonight. You can also check out our NEW college basketball player prop odds tool for the latest college basketball odds on any market across legal sportsbooks in your region.
💰 Cooper Flagg Over 1.5 made 3-pointers ⭐⭐⭐⭐
The Hurricanes were beaten so badly that Flagg only played 28 minutes while taking 11 shots the last time Duke played Miami. That's why I'm avoiding taking the Over on his 19.5 points at our best sports betting sites. He's gone Under 19.5 in five of his last six games, with Duke building huge leads during many of those contests.
Instead, I'm taking Flagg to hit at least two threes for the 12th time this season after he went 2-for-5 from behind the arc the last time the Blue Devils played the Hurricanes. Miami has been horrendous defending the perimeter, too.
The Hurricanes are allowing the most made 3-pointers per game (9.6) and the highest 3-point percentage (39.6%) in ACC play. Flagg has hit at least two threes in four of his last seven outings (57.1%), making this +105 price at BetMGM a great value.
Best odds: +105 via BetMGM (bet $10 to win $10.50)
Duke vs. Miami AI prediction
We asked ChatGPT, the popular chatbot from OpenAI, to offer its best AI prediction for Duke vs. Miami tonight - including its pick to win and exact score prediction. ChatGPT is a large language model and is not specifically designed for sports betting predictions.
🤖 AI score prediction: Duke 85, Miami 62
With Cooper Flagg leading Duke’s dominant frontcourt and the team's ability to push the pace in transition, the Blue Devils should take advantage of Miami’s defensive struggles and lack of interior depth. The projected final score is Duke 85, Miami 62.
- Duke has been dominant this season with freshman standout Flagg continuing to impress and contributing significantly to the team's success
- Miami has been facing challenges, including the resignation of Larranaga after Christmas, leading to interim head coach Courtney taking over
- Duke's balanced scoring attack, with Flagg and Knueppel leading the way, poses a significant challenge to a struggling Miami defense
This game is crucial for Duke as they aim to maintain their momentum heading into the postseason, while Miami seeks to end its campaign on a positive note.
📊 Live Duke vs. Miami odds
Here are the latest odds for Duke vs. Miami, which update in real time. You can also check out the rest of our NCAAB scores as they happen.
🔢 Duke vs. Miami opening odds
Here's a look at the opening odds for Duke vs. Miami according to bet365.
- Spread: Duke -22.5 (-110) | Miami +22.5 (-110)
- Over/Under: Over 151 (-115) | Under 151 (-105)
- Moneyline: Duke -8000 | Miami +1800
📺 How to watch Duke vs. Miami tonight
📅 Date: Tuesday, Feb. 25, 2025
🕗 Time: 7 p.m. ET
📍 Location: Watsco Center (Coral Gables, Fla.)
📺 TV: ESPN
💻 Streaming: ESPN+
❓ Duke vs. Miami FAQs
Who is favored to win Duke vs. Miami?
Duke is a -3600 moneyline favorite, implying a 97.30% probability the Blue Devils beat Miami.
What are the odds for Duke vs. Miami?
Duke is a 22-point road favorite vs. Miami, with the game total sitting at 150.5.
What time is Duke vs. Miami tonight?
Duke vs. Miami is tonight at 7 p.m. ET on ESPN
📈 College basketball betting odds pages
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