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March Madness AI Predictions Today: Exact Score Picks for Friday's NCAA Tournament Games

C Jackson Cowart

Last Updated: March 21, 2025 10:05 PM EDT • 1 min 56 sec read.

March Madness AI Predictions Today: ChatGPT's Exact Score Picks for Every NCAA Tournament Game
Maryland Terrapins guard Selton Miguel (9) goes up for a basket. Photo by Grace Smith / IndyStar.

Each day, we're compiling all of our March Madness AI predictions with picks and exact score projections courtesy of ChatGPT for every game in the NCAA Tournament. Our March Madness AI bracket predictions have gotten off to a blistering start, but can ChatGPT predict the score for all 16 games today? Here are our AI-generated insights.

👉 Can't get enough March Madness action? Check out the rest of our March Madness first-round expert picks as part of our March Madness predictions.

🤖 March Madness AI predictions & exact score projections today

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🏀 Michigan State vs. Bryant prediction, 10 p.m. ET (TBS)

🖥️ AI score prediction: Michigan State 85, Bryant 65

  • Bryant has struggled in matchups against Big Ten teams, having lost their last nine games against such opponents. 
  • Bryant’s scoring has been more inconsistent against higher-level teams, and they’ll struggle to maintain a high level of offense against Michigan State’s defense.
  • Michigan State's defense is a strong factor. They are known for their ability to lock down opponents, which will be crucial against a less-experienced team like Bryant.

🧠 For more expert (human) analysis, check out our Michigan State vs. Bryant prediction.

📊 Michigan State vs. Bryant odds

🏀 Oregon vs. Liberty prediction, 10:10 p.m. ET (truTV)

🖥️ AI score prediction: Liberty 68, Oregon 64

  • Oregon is making its second straight NCAA Tournament appearance and ninth under Altman. It has won at least one game in each of those appearances while reaching as far as the Final Four in 2017
  • Liberty’s disciplined defense will be the key. Its ability to control the tempo and limit Oregon’s fast break and 3-point shooting will give it an edge in a tightly contested game
  • Liberty’s defensive discipline and slow-tempo approach will keep Oregon from getting into a rhythm, leading to a narrow but important win for the Flames

🧠 For more expert (human) analysis, check out our Oregon vs. Liberty prediction.

📊 Oregon vs. Liberty odds

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Written By:
C Jackson Cowart
C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.