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March Madness AI Predictions Today: Sweet 16 Picks & Exact Score for Thursday's NCAA Tournament Games

C Jackson Cowart

Last Updated: March 27, 2025 1:09 PM EDT • 3 min 10 sec read.

March Madness AI Predictions Today: ChatGPT's Sweet 16 Picks & Exact Score Predictions
Pictured: Texas Tech Red Raiders head coach Grant McCasland reacts after their win against the Drake Bulldogs. Photo by Nick Tre. Smith via Imagn Images.

Each day, we're compiling all of our March Madness AI predictions with picks and exact score projections courtesy of ChatGPT for every game in the NCAA Tournament.

Our March Madness AI bracket predictions rank among the 2% of all brackets entering the Sweet 16, but will our AI-generated insights via ChatGPT have the same success today?

👉 Want to bet on the Sweet 16? Check out the latest March Madness Sweet 16 odds & full schedule and the rest of our March Madness predictions.

🤖 March Madness AI predictions & Sweet 16 exact score projections today

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🏀 Alabama vs. BYU prediction, 7:09 p.m. ET (CBS), East Region

🖥️ AI score prediction: Alabama 81, BYU 67

  • With a potent offense, Alabama is built to outscore opponents. BYU’s defense will struggle to contain Alabama’s up-tempo game, which could lead to fast-break points and easy baskets.
  • Alabama is one of the best rebounding teams in the nation, especially on the offensive glass. BYU will need to limit second-chance opportunities, but Alabama’s size and athleticism will likely overwhelm the Cougars
  • Alabama’s superior offense, rebounding, and overall depth make it a heavy favorite in this matchup. BYU may keep it competitive early, but Alabama's pace and talent should take control by the second half.

🧠 For more expert (human) analysis, check out our Alabama vs. BYU prediction.

📊 Alabama vs. BYU odds

🏀 Florida vs. Maryland prediction, 7:39 p.m. ET (TBS/truTV), West Region

🖥️ AI score prediction: Florida 77, Maryland 74

  • Florida's offense, averaging 85.4 points per game, ranks third nationally. Their high-scoring capability, led by All-American guard Walter Clayton Jr., will challenge Maryland's defense.
  • Maryland's freshman standout, Derik Queen, has been instrumental in their tournament run, notably hitting a buzzer-beater to advance past Colorado State. His performance under pressure could be pivotal against Florida.
  • Florida has failed to cover the spread in their tournament games so far, indicating they might be overvalued by oddsmakers. This trend suggests that Maryland could perform better than the spread implies.

🧠 For more expert (human) analysis, check out our Florida vs. Maryland prediction.

📊 Florida vs. Maryland odds

🏀 Duke vs. Arizona prediction, 9:39 p.m. ET (CBS), East Region

🖥️ AI score prediction: Duke 75, Arizona 71

  • The Blue Devils have been elite on defense, ranking in the top five nationally in adjusted defensive efficiency. Arizona’s high-powered offense will be tested, especially by Duke’s athleticism and length.
  • Both teams have been prone to turnovers in high-pressure situations. Duke thrives in transition after creating turnovers, so controlling the ball will be crucial for Arizona’s chances.
  • Both teams are strong on the boards, but Duke’s size and depth in the frontcourt give it a slight advantage. Arizona’s ability to dominate the paint will need to be neutralized by Duke’s physicality and defensive schemes.

🧠 For more expert (human) analysis, check out our Duke vs. Arizona prediction.

📊 Duke vs. Arizona odds

🏀 Texas Tech vs. Arkansas prediction, 10:09 p.m. ET (TBS/truTV), West Region

🖥️ AI score prediction: Texas Tech 78, Arkansas 70

  • Texas Tech's offense, averaging 80.8 points per game, has been efficient, ranking 28th nationally. Their ability to score consistently could challenge Arkansas' defense, which allows 71.0 points per game.
  • Arkansas has demonstrated resilience in the tournament, notably with a 75-66 victory over St. John's to advance to the Sweet 16. However, facing a higher-seeded Texas Tech team presents a significant challenge.
  • Texas Tech's defense has been formidable, allowing 67.6 points per game, which could pose difficulties for Arkansas' offense that averages 76.6 points per game.

🧠 For more expert (human) analysis, check out our Texas Tech vs. Arkansas prediction.

📊 Texas Tech vs. Arkansas odds

🏀 Best March Madness odds, predictions & expert picks today

✅ More Sweet 16 picks & predictions

🗓️ Sweet 16 schedule & TV info today

  • No. 2 Alabama vs. No. 6 BYU, 7:09 p.m. ET (CBS), East Region
  • No. 1 Florida vs. No. 4 Maryland, 7:39 p.m. ET (TBS/truTV), West Region
  • No. 1 Duke vs. No. 4 Arizona, 9:39 p.m. ET (CBS), East Region
  • No. 3 Texas Tech No. 10 Arkansas, 10:09 p.m. ET (TBS/truTV), West Region

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Written By:
C Jackson Cowart
C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.