March Madness AI Predictions: ChatGPT's Best Bets for the 2025 NCAA Tournament

C Jackson Cowart

Last Updated: March 20, 2025 1:38 AM EDT • 5 min 45 sec read. Twitter link Google News Link

ChatGPT's March Madness AI Predictions & NCAA Tournament Best Bets — Pictured: Duke Blue Devils forward Cooper Flagg (2) blocks a shot by Auburn Tigers guard Denver Jones (2). Photo by Rob Kinnan / Imagn Images.

We've already turned to ChatGPT for its March Madness AI bracket predictions, but we're gathering all of its best bets and picks ahead of the NCAA Tournament first round.

From its March Madness championship prediction to its best first-round upsets, we're taking a look at the best value bets for the NCAA Tournament according to ChatGPT.

👉 Looking for the perfect March Madness bracket? We simulated every NCAA Tournament game 1,000 times to help with your bracket predictions.

🏀 March Madness AI predictions: Who will win the 2025 NCAA Tournament?

Let's start off with a caveat: ChatGPT is a large language model, and these picks are for entertainment only. That said, the AI chatbot is capable of identifying trends that bettors may overlook, which makes it compelling at the very least to see what it picks.

There must be a little bit of human hiding inside that robot's mind because it has the same March Madness prediction as everyone else: ChatGPT predicts Duke will win the NCAA Tournament.

🏆 ChatGPT's best bet to win the NCAA Tournament: No. 1 Duke

📊 Duke's best odds to win NCAA Tournament: +320 via DraftKings

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It shouldn't surprise anyone to see ChatGPT pick the Blue Devils, who are the most popular choice among March Madness media expert bracket picks and our very own college basketball experts at Sportsbook Review, too.

It's easy to see why - Duke boasts three of the best players in March Madness in Cooper Flagg, Kon Knueppel, and Khaman Maluach, while veteran leader Tyrese Proctor is perhaps the most overqualified "role player" in the country. That's why the Blue Devils are dealing among the favorites by the March Madness odds entering the first round.

👉 More March Madness predictions: One of these 8 teams will win the NCAA Tournament

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👠 March Madness AI predictions: Who will be this year's Cinderella pick?

We're all looking to make the best March Madness upset picks before they happen, but it's hard to know which team will etch their name in tournament lore entering the first round.

Our ChatGPT bracket predictions didn't offer many candidates with most potential Cinderella teams losing in the first or second round. That said, it did pick one double-digit seed to advance all the way to the Sweet 16.

🚀 ChatGPT's best bet to reach the Sweet 16: No. 12 UC San Diego

📊 UC San Diego's best odds to reach Sweet 16: +390 via DraftKings

UC San Diego is one of the trendiest picks in the March Madness bracket this year after posting a 30-4 record behind star transfer Aniwaniwa Tait-Jones, who is averaging 19.5 points on 57.6% shooting - both of which rank in the top 30 nationally.

Our college basketball expert Rob Paul also has the Tritons advancing to the Sweet 16 in his March Madness expert bracket, and you can still get juicy odds on the Big West champions to reach the Sweet 16 via DraftKings.

👉 Looking for the next Cinderella? We broke down our March Madness bracket sleepers including our best upset picks and Cinderellas in every region.

🚨 March Madness AI predictions: What are the best first-round upsets?

Nothing beats nailing one of your March Madness upset predictions, especially when it involves a double-digit seed from a conference nobody has heard of.

It's even better when that team is full of a bunch of former Division-II stars looking to make their name in the greatest tournament in college sports. And ChatGPT is buying the hype on a No. 12 seed that our best sports betting sites aren't showing much respect.

👀 ChatGPT's best upset pick in the first round: No. 11 Drake over No. 6 Missouri

📊 Drake's best odds to beat Missouri: +220 via bet365

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While ChatGPT picked seven double-digit seeds to advance in the first round - including two No. 12 seeds - none have longer odds across our best sportsbooks than Drake to advance to the second round of the NCAA Tournament.

That feels like an oversight by bet365 and others, as the Bulldogs have a veteran lineup led by a slew of former D-II transfers and force turnovers at the highest rate in the country (14.6%). That sounds like the perfect upset recipe for one of this year's best March Madness Giant Killers.

👉 Want more upset picks? Check out our best March Madness 12 vs. 5 seed upsets and our guide on how to predict March Madness upsets.

4️⃣ March Madness AI predictions: Who will reach the Final Four?

For all of the upsets that have come to define the NCAA Tournament, the final four teams in the 68-team field tend to be mostly the March Madness top seeds.

That said, all four No. 1 seeds have made the Final Four just once in tournament history, and ChatGPT is only picking two - Duke and Auburn - to reach the semifinals this year. And it's backing a dark horse to emerge from the West Region.

🎯 ChatGPT's best Final Four pick: No. 3 Texas Tech

📊 Texas Tech's best odds to reach Final Four: +560 via Caesars

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Even though Texas ranks seventh in KenPom with the sixth-best offensive efficiency in the country, the Red Raiders were denied a top-two seed and landed in arguably the toughest region in the NCAA Tournament.

None of that is deterring ChatGPT, which picked Grant McCasland's group to win the West Region and reach the Final Four for the first time since a trip to the title game in 2019. And a bet on that happening would turn a $10 wager into a $56 profit at Caesars.

👉 Too much chalk in your bracket? Check out our March Madness Final Four expert picks with our best sleepers and long shots to reach the Final Four.

🤖 March Madness AI predictions: ChatGPT's best bets for the NCAA Tournament

Bet	Pick (odds)	Implied probability
🏆 Pick to win NCAA Tournament	Duke (+320)	23.81%
👠 Best Sweet 16 Cinderella	UC San Diego (+390)	20.41%
🚨 Best first-round upset	Drake (+220)	31.25%
4️⃣ Best Final Four pick	Texas Tech (+560)	15.15%

🏀 More March Madness expert predictions

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Written By:
C Jackson Cowart

C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.