Skip to main content
Best March Madness Parlay Bets Today: Final Four Moneyline Picks
Pictured: Duke Blue Devils guard Sion James (14) and forward Cooper Flagg (2) celebrate in the 2025 NCAA Tournament. Photo by Vincent Carchietta / Imagn Images.

Our best March Madness Final Four parlay bets focus on both NCAA Tournament semifinal matchups with a two-leg parlay based on our expert score predictions for tonight's games:

  • No. 1 Auburn vs. No. 1 Florida, 6:09 p.m. ET (CBS)
  • No. 1 Duke vs. No. 1 Houston, 8:49 p.m. ET (CBS)

๐Ÿ‘‰ Want to bet on the Final Four? Check out our March Madness Final Four expert picks as part of our March Madness predictions.  

๐Ÿ’ฐ Our best March Madness Final Four parlay bets for the NCAA Tournament

Here are the best odds for our March Madness Final Four parlay using our NEW parlay calculator to instantly determine the best price across our best sports betting sites.

๐Ÿ”ฅ Florida (-154) vs. Auburn
๐Ÿ”ฅ Duke (-238) vs. Houston

๐Ÿš€ Best parlay odds: +134 via ESPN BET ($10 to win $13.43)

Up To $600 In Bonuses

Terms and conditions apply

Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission. 21+. Gambling can be addictive, please play responsibly

๐Ÿ”ฎ March Madness score predictions & Final Four moneyline odds tonight

Our NEW college basketball player prop odds tool can help you find the best odds for any March Madness market across legal sportsbooks in your area!

๐Ÿ€ Auburn vs. Florida prediction, 6:09 p.m. ET (CBS)

๐ŸŽฏ Score prediction: Florida 83, Auburn 77
๐Ÿ’ฐ Best Houston moneyline odds: -149 via Caesars

Here's what Mike Spector expects to see today in Auburn vs. Florida:

"Florida is 16-1 in its last 17 games and won four games against teams that were either No. 1 or No. 2 seeds in the NCAA Tournament by a combined 45 points in that span. Favorites were also a perfect 12-0 SU in the Sweet 16 and Elite Eight and are 50-13 overall so far in the NCAA Tournament."

๐Ÿ‘‰ For more analysis & latest odds, check out our full Auburn vs. Florida prediction and our best Auburn vs. Florida player props.

๐Ÿ“Š Auburn vs. Florida odds

๐Ÿ€ Duke vs. Houston prediction, 8:49 p.m. ET (CBS)

๐ŸŽฏ Score prediction: Duke 69, Houston 66
๐Ÿ’ฐ Best Michigan State moneyline odds: -238 via ESPN BET

Here's what Mike Spector expects to see tonight in Duke vs. Houston:

"The Blue Devils have won 31 of their last 32 games, with three of their four NCAA Tournament wins coming by at least 20 points. However, players like Jโ€™Wan Roberts and LJ Cryer for Houston have Final Four experience, which will help lead them to cover a spread that has increased from an opening line of +4.5." 

๐Ÿ‘‰ For more analysis & latest odds, check out our full Duke vs. Houston prediction and our best Duke vs. Houston player props.

๐Ÿ“Š Duke vs. Houston odds

๐Ÿ†š Final Four game predictions

๐Ÿ€ Best March Madness odds, predictions & expert picks for Final Four

๐Ÿ’ฐ March Madness betting odds pages

๐Ÿ‘‘ Best March Madness betting sites

Ready to place your March Madness bets? Check out the best March Madness betting promos from the best March Madness betting sites as determined by our expert team at Sportsbook Review.

(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.

Not intended for use in MA.
Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.