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March Madness Predictions Today: Expert Picks & Exact Score for Every NCAA Tournament Game

C Jackson Cowart

Last Updated: March 21, 2025 10:04 PM EDT • 1 min 61 sec read.

March Madness Predictions Today: Friday's Expert Picks & Exact Score for Every Game
Pictured: Michigan State Spartans guard Jeremy Fears Jr. (1) celebrates in the first half. Photo by Trevor Ruszkowski / Imagn Images.

The NCAA Tournament delivered two double-digit upsets on the opening day of the first round, and our March Madness predictions today expect another such upset with Friday's action tipping off at 12:15 a.m. ET and extending into the night.

We have you covered from every angle with our March Madness predictions today, including our best picks against the spread and exact score predictions for all 16 games on the second day of the 2025 NCAA Tournament.

👉 Can't get enough March Madness action? Check out the rest of our March Madness first-round expert picks as part of our March Madness predictions.

💰 March Madness predictions, NCAA Tournament odds & expert picks today

📅 Check out the full March Madness first-round schedule & opening odds.

🏀 Michigan State vs. Bryant prediction, 10 p.m. ET (TBS)

✅ Michigan State to cover the spread: -17.5 ⭐⭐⭐⭐⭐
🎯 Score prediction: Michigan State 93, Bryant 64

Here's why Phil Wood is picking Michigan State to cover the spread (-17.5):

"This massive spread is warranted. Although Michigan State lost by three to the Wisconsin Badgers in the Big Ten semifinals, they are among the March Madness odds contenders and one of the hottest teams entering the tournament. They have won eight of their last nine, with seven of those wins over ranked opponents. Five of those seven wins were by double digits."

👉 For more analysis, check out our Michigan State vs. Bryant prediction.

📊 Michigan State vs. Bryant odds

🏀 Oregon vs. Liberty prediction, 10:10 p.m. ET (truTV)

✅ Oregon to cover the spread: -6.5 ⭐⭐
🎯 Score prediction: Oregon 77, Liberty 68

Here's why Mike Spector is picking Oregon to cover the spread (-6.5):

"The Flames run an efficient offense that ranks in the top five in the country in effective field goal percentage and 3-point shooting percentage. But Liberty struggles with athletic teams, evidenced by allowing 82 points per game to Kennesaw State in the final two matchups."

👉 For more analysis, check out our Oregon vs. Liberty prediction.

📊 Oregon vs. Liberty odds

🏀 Best March Madness odds, predictions & expert picks today

Here are our best March Madness picks for Friday's first-round action:

💰 March Madness betting odds pages

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Ready to place your March Madness bets? Check out the best March Madness betting promos from the best March Madness betting sites as determined by our expert team at Sportsbook Review.

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Written By:
C Jackson Cowart
C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.