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March Madness Sweet 16 Predictions Today: Expert Picks & Scores for Every NCAA Tournament Game

C Jackson Cowart

Last Updated: March 27, 2025 1:05 PM EDT • 3 min 14 sec read.

March Madness Sweet 16 Predictions Today: Thursday's Expert Picks & NCAA Tournament Scores
Pictured: Arkansas Razorbacks head coach John Calipari in an NCAA Tournament game against the St. John's Red Storm. Photo by Gregory Fisher via Imagn Images.

The two favorites by the March Madness odds take the court tonight in the Sweet 16, as we offer our March Madness predictions today for all four NCAA Tournament games:

  • No. 2 Alabama vs. No. 6 BYU, 7:09 p.m. ET (CBS)
  • No. 1 Florida vs. No. 4 Maryland, 7:39 p.m. ET (TBS/truTV)
  • No. 1 Duke vs. No. 4 Arizona, 9:39 p.m. ET (CBS)
  • No. 3 Texas Tech No. 10 Arkansas, 10:09 p.m. ET (TBS/truTV)

👉 Want to bet on the Sweet 16? Check out the latest March Madness Sweet 16 odds & full schedule and the rest of our March Madness predictions.

💰 March Madness Sweet 16 predictions & NCAA Tournament odds today

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🏀 No. 2 Alabama vs. No. 6 BYU, 7:09 p.m. ET (CBS), East Region

✅ ATS prediction: BYU to cover the spread +4.5 ⭐⭐⭐⭐⭐
🎯 Score prediction: BYU 94, Alabama 90

Here's why Mike Spector is picking BYU to cover the spread (+4.5):

"BYU will not mind getting up and down with Alabama, and the Cougars are built to expose the Crimson Tide’s defensive inefficiencies, as Alabama has allowed 90-plus points in five of its last 11 games. This line feels overinflated after Alabama beat a horrifically poor-shooting Saint Mary’s team that had gone 12-for-68 from 3-point range over its last four games."

👉 For more analysis & latest odds, check out our Alabama vs. BYU prediction.

📊 Alabama vs. BYU odds

🏀 No. 1 Florida vs. No. 4 Maryland, 7:39 p.m. ET (TBS/truTV), West Region

✅ ATS prediction: Maryland to cover the spread +6.5 ⭐⭐⭐⭐
🎯 Score prediction: Maryland 76, Florida 74

Here's why Isaiah Sirois is picking Maryland to cover the spread (+6.5):

"The Florida Gators are great, as their second-shortest March Madness odds indicate, but the Maryland Terrapins might be severely under-seeded. Since Feb. 1, the Gators are an impressive third in T-Rank, mainly due to their second-ranked offense–but the Terps are right on their heels in seventh. Unlike Florida, Maryland’s success stems from its defense, which is first nationally in adjusted defensive efficiency in that sample."

👉 For more analysis & latest odds, check out our Florida vs. Maryland prediction.

📊 Florida vs. Maryland odds

🏀 No. 1 Duke vs. No. 4 Arizona, 9:39 p.m. ET (CBS), East Region

✅ ATS prediction: Arizona to cover the spread +9.5 ⭐⭐⭐⭐
🎯 Score prediction: Duke 80, Arizona 75

Here's why Mike Spector is picking Arizona to cover the spread (+9.5):

"Duke has beaten its opponents by 25 points per game during its 13-game winning streak. And its most impressive non-conference victory of the season was a 69-55 road win at Arizona, which was also the Wildcats’ third-lowest scoring output of the season. But Arizona head coach Tommy Lloyd has shown an ability to get his team to play much better in 'revenge' spots."

👉 For more analysis & latest odds, check out our Duke vs. Arizona prediction.

📊 Duke vs. Arizona odds

🏀 No. 3 Texas Tech vs. No. 10 Arkansas, 10:09 p.m. ET (TBS/truTV), West Region

✅ ATS prediction: Texas Tech to cover the spread -5.5 ⭐⭐⭐⭐
🎯 Score prediction: Texas Tech 80, Arkansas 70

Here's why Isaiah Sirois is picking Texas Tech to cover the spread (-5.5):

"While John Calipari and the Arkansas Razorbacks have a ton of momentum, their March Madness resume isn’t all that impressive. They beat a bad Kansas team that looked lost with Hunter Dickinson on the floor and a St. John’s team that couldn’t make a shot to save its life. If you’re looking for a Cinderella, this probably isn’t it."

👉 For more analysis & latest odds, check out our Texas Tech vs. Arkansas prediction.

📊 Texas Tech vs. Arkansas odds

🏀 Best March Madness odds, predictions & expert picks today

✅ More Sweet 16 picks & predictions

🗓️ Sweet 16 schedule & TV info today

  • No. 2 Alabama vs. No. 6 BYU, 7:09 p.m. ET (CBS), East Region
  • No. 1 Florida vs. No. 4 Maryland, 7:39 p.m. ET (TBS/truTV), West Region
  • No. 1 Duke vs. No. 4 Arizona, 9:39 p.m. ET (CBS), East Region
  • No. 3 Texas Tech No. 10 Arkansas, 10:09 p.m. ET (TBS/truTV), West Region

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Written By:
C Jackson Cowart
C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.