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Mount St. Mary’s vs. American Prediction, Odds & Preview Tonight: Best First Four Picks
Pictured: American University Eagles forward Matt Rogers (15) shoots. Photo by Kyle Ross-Imagn Images.

The Mount St. Mary's Mountaineers (22-12) take on the American Eagles (22-12) tonight at 6:40 p.m. ET (truTV) at UD Arena in Dayton, Ohio in a bid to claim the No. 16 seed in the East Region of the March Madness bracket. My Mount St. Mary's vs. American prediction, odds, and preview call for the 2.5-point betting favorites to take care of business.

Before you can finalize your March Madness predictions, you'll need the results of this game - one of two First Four games being played tonight that will finalize the 2025 March Madness bracket. The winner gets the grand prize of playing Duke on Friday.

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🏀 Mount St. Mary’s vs. American prediction & picks tonight

Here are my best Mount St. Mary’s vs. American predictions for tonight's First Four matchup of the NCAA Tournament; use our parlay calculator to get the best odds for any same-game parlay:

✅ Against the spread pick: American -2.5 (-110 via BetMGM) vs. Mount St. Mary’s ⭐⭐⭐
🔥 Best player prop bet: Matt Rogers Over 1.5 3-pointers (-154 via FanDuel) ⭐⭐
🎯 Exact score prediction: American 69, Mount St. Mary’s 64 (+15000 via DraftKings)

👉 Want more picks? Check out our latest college basketball picks and the rest of our March Madness first-round predictions.

👀 Mount St. Mary's vs. American betting insights

Betting insights via BetMGM on straight bets only.

Against the spread:

  • Opening spread: American -1.5 | Current spread: American -2.5
  • Bets: 52% on Mount St. Mary's | 48% on American
  • Handle: 53% on Mount St. Mary's | 47% on American

Over/Under:

  • Opening total: 133.5 | Current total: 129.5
  • Bets: 51% on Over | 49% on Under
  • Handle: 35% on Over | 65% on Under

Moneyline:

  • Opening moneyline: Mount St. Mary's +110 | American -130
  • Current moneyline: Mount St. Mary's +118 | American -145
  • Bets: 69% on Mount St. Mary's | 31% on American
  • Handle: 33% on Mount St. Mary's | 67% on American

👉 Want AI-driven bracket insights? Check out our full March Madness AI bracket predictions with score predictions for every game.  

🏆 Best Mount St. Mary’s vs. American pick, player prop bet & score prediction

Our NEW college basketball player prop odds tool can help you find the best odds for any March Madness market across legal sportsbooks in your area!

✅ American to cover the spread: -2.5 ⭐⭐⭐

The Patriot League champions are worth backing in this First Four matchup due to their experience and continuity edge over Mount St. Mary’s.

The Eagles lead the nation in minutes continuity (74.7%), meaning players understand their roles on this team. They are also 50th in Division I experience. For comparison, Mount St. Mary’s is 175th in the former metric and 240th in the latter.

Fun note: The Eagles might try to tip forward if they win the opening tipoff in hopes of a quick basket, something they attempted in the conference title game.

📊 Best odds: -110 via BetMGM ($10 to win $9.09)

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🔥 Matt Rogers Over 1.5 made 3-pointers ⭐⭐

Senior Matt Rogers, a 6-foot-9 forward, is American’s best player. He’s averaging 17 points and 5.6 rebounds per game on 55.6% shooting.

Rogers can stretch the floor, shooting 39.9% from long range this season. He’s averaging 1.7 triples per game, clearing this prop in four of his past seven outings.

Mount St. Mary’s ranks 334th in 3-point rate allowed (44.5%), so I like Rogers’ chances of knocking down multiple triples.

📊 Best odds: -154 via FanDuel (bet $10 to win $6.49)

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🎯 Score prediction: American 69, Mount St. Mary’s 64

American scored 71-plus points in all three games during the conference tournament, but this First Four matchup could be low-scoring. The Eagles’ experience should ultimately prevail in a 69-64 affair.

📊 Best odds: +15000 via DraftKings ($10 to win $1,500)

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🤖 Mount St. Mary’s vs. American AI prediction

For entertainment purposes, we asked ChatGPT to analyze historical trends and live NCAA Tournament stats before predicting the winner and exact score for Mount St. Mary's vs. American. Our AI prediction projects a final score of American 71, Mount St. Mary’s 67.

🖥️ AI score prediction: American 71, Mount St. Mary’s 67

  • A graduate student forward, Matt Rogers leads American with an average of 17 points and 5.6 rebounds per game.
  • Dola Adebayo averages 13.2 points and 6.9 rebounds per game for Mount St. Mary’s.
  • This game marks the 71st meeting between the two programs, with American University leading the series 38-32.

🤔 Betting takeaway: ChatGPT's AI prediction would mean American covering the spread (-2.5) and a total of Over 129.5 points. ChatGPT is not a dedicated sports betting model, but it can identify data that March Madness bettors might overlook.

📊 Live Mount St. Mary’s vs. American odds

Follow the latest live March Madness college basketball odds and real-time NCAA Tournament scores for the first round.

🔢 Mount St. Mary’s vs. American opening odds

  • Spread: Mount St. Mary’s +2.5 (-105) | American -2.5 (-115)
  • Moneyline: Mount St. Mary’s +120 | American -145
  • Over/Under: Over 131.5 (-110) | Under 131.5 (-110)

📅 Check out the full March Madness first-round schedule and opening odds.

🔮 First Four expert picks

📺 How to watch Mount St. Mary’s vs. American: NCAA Tournament First Four

📅 Date: Wednesday, March 19
🕗 Time: 6:40 p.m. ET
📍 Location: UD Arena (Dayton, Ohio
📺 TV: truTV
💻 Streaming: March Madness Live

💰 March Madness betting odds pages

👑 Best March Madness betting sites

Ready to place your March Madness bets? Check out the best March Madness betting promos from the best March Madness betting sites as determined by our expert team at Sportsbook Review.

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