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San Francisco 49ers running back Christian McCaffrey rushes the ball against the Seattle Seahawks, and he headlines our top 49ers vs. Packers player prop bets.
San Francisco 49ers running back Christian McCaffrey rushes the ball against the Seattle Seahawks. Photo by David Gonzales via Imagn Images.

Christian McCaffrey and the San Francisco 49ers will look to pick up a much-needed win against the Green Bay Packers when they travel to Lambeau Field on Sunday.

Rainy conditions are expected for Sunday’s 4:25 p.m. ET (FOX) game at in Green Bay. How will the weather impact our best 49ers vs. Packers prop bet picks?

Jordan Love has struggled to take care of the ball this season. Despite his turnover troubles, the Packers are favored by three points.

Will Love and Jayden Reed lead the Packers to victory, or will McCaffrey lead his team to a huge road win?

We're looking at this game and many more as part of our NFL Week 12 predictions.

49ers vs. Packers NFL player prop bets: Sunday

Odds as of Friday and subject to change.

  • Christian McCaffrey touchdown pick: 2+ touchdowns (+470 via FanDuel) ⭐⭐⭐
  • Jordan Love Over 0.5 interceptions (-135 via bet365) ⭐⭐⭐⭐⭐
  • Jayden Reed Over 48.5 receiving yards (-110 via bet365) ⭐⭐⭐⭐

NFL picks made Friday; odds subject to change. Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

49ers vs. Packers touchdown pick

Christian McCaffrey to score 2+ touchdowns (+470) ⭐⭐⭐

In his two games this season, McCaffrey has yet to score a touchdown. While this may alarm some bettors, this is a player who scored 21 touchdowns in the regular season last year, and he had at least one score in 16 of his 19 games including the postseason.

The Packers have the 10th-best scoring defense in the league, but they’re allowing one rushing touchdown per game this season.

With sloppy weather conditions expected to play a factor, McCaffrey will see plenty of touches, as even in perfect weather, he’s had 42 touches in two games this season. That came with Brock Purdy under center, and he'll already been ruled out Sunday.

In last year’s postseason, McCaffrey scored two touchdowns against the Packers. Three of our best sports betting sites offering this prop seem to remember that, as they have the price listed at +333 or worse.

However, FanDuel seems to be basing its price on McCaffrey’s performance this season, and the sportsbook is offering a phenomenal price of +470.

Best odds: +470 via FanDuel | Implied probability: 17.54%

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Best 49ers vs. Packers prop bets

Jordan Love Over 0.5 interceptions (-135) ⭐⭐⭐⭐⭐

Love has already thrown 11 interceptions this season - tied for the most in the NFL - and he’s thrown at least one pick in every single game in which he’s appeared.

Last week, he attempted only 17 passes, and he completed 76.5% of those attempts. However, he still managed to throw one interception.

The 49ers are averaging 1.1 interceptions per game, which ranks fifth in the NFL. Six of the last seven quarterbacks they’ve faced have thrown an interception against them, and three of those quarterbacks threw two in one game.

Considering how horrible Love has been at protecting the football, it’s surprising that this price is as good as it is.

These -135 odds still imply a 57.45% chance that Love throws a pick, but the price is great when compared to the -147 Caesars is offering.

Best odds: -135 via bet365 | Implied probability: 57.45%

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Jayden Reed Over 48.5 receiving yards (-110) ⭐⭐⭐⭐

The weather conditions will be less than ideal, and the Packers are going against the eighth-best pass defense in the NFL. Yet this total feels too low for the Packers’ leading receiver.

Reed managed just two catches for 23 yards last week, but he has six games with at least 50 yards this year.

If weather is a major reason for this low number, I’m not concerned at all. The conditions won’t be nearly as bad as they were three weeks ago against the Detroit Lions, and Reed had five catches for 113 yards in that game.

And if this total is low strictly because of the 49ers’ defense, just remember that they did allow CeeDee Lamb to go for 146 yards earlier this season, and Jaxon Smith-Njigba had 10 catches for 110 yards last week.

All of our best sports betting apps have this total set at 48.5, but bet365 is offering the best price at -110.

Best odds: -110 via bet365 | Implied probability: 52.38%

49ers vs. Packers game info

  • When: Sunday, Nov. 24
  • Kickoff: 4:25 p.m. ET
  • Where: Lambeau Field (Green Bay, Wis.)
  • How to watch: FOX
  • Weather: 41 degrees, 40% chance of precipitation, wind 11 mph E
  • Favorite: Green Bay -3 (-105 via BetMGM)

NFL betting odds pages

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