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Denver Broncos quarterback Bo Nix reacts after the game against the Las Vegas Raiders as we look at our Bo Nix player prop picks.
Denver Broncos quarterback Bo Nix reacts after the game against the Las Vegas Raiders. Photo by Kirby Lee/Imagn Images.

Josh Allen and the Buffalo Bills will draw the majority of the headlines and attention heading into this Wild Card Weekend matchup, but don’t be surprised if Denver Broncos coach Sean Payton has prepared his rookie quarterback to rise to the moment.

Our Bo Nix player prop picks predict a sneaky good game for the Denver offense despite the Broncos coming in as massive underdogs to the Bills.

The Bills (-8.5) host the Broncos at Highmark Stadium in Orchard Park, N.Y, on Sunday at 1 p.m. ET (CBS). Our NFL playoff bracket predictions forecast a game that's closer than some anticipate.

Bo Nix prop bets: Wild Card Weekend

NFL odds as of Friday. Track the NFL scores for the latest line movement and matchup info.

Bo Nix Wild Card Weekend player props

NFL picks made Friday. Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Bo Nix Over 223.5 passing yards (-113) ⭐⭐⭐⭐

The betting market is going gaga over the Bills heading into this matchup with the Broncos.

However, Buffalo wrapped up its season facing the New England Patriots twice and the New York Jets. We haven’t seen this Bills defense against any vaunted offenses since it permitted 40-plus points to the Los Angeles Rams and Detroit Lions during consecutive weeks earlier in December.

The Bills rank 24th in pass defense, allowing 226.1 passing yards per game. Buffalo allowed 300-plus passing yards three times over five games against eventual playoff teams this season.

Bo Nix has been playing quality football down the stretch. He's racked up a passing yardage total that eclipses the yardage of this prop at FanDuel and Caesars in five of his past seven games.

Unless the Broncos find themselves down by a bunch, their odds of covering, which Mike Spector expects to happen in his Broncos vs. Bills prediction, should increase if Nix hits the Over on this prop. 

Best odds: -113 via FanDuel | Implied probability: 53.05%

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Bo Nix Over 5.5 rushing attempts (+115) ⭐⭐⭐⭐

I’m more confident in Nix’s proclivity to take off and run with the football in this matchup than I am in his ability to successfully evade Buffalo's linebackers while doing it.

While the rushing yardage line is somewhat attainable at 26.5 yards, I could envision Nix diving forward for meager gains with frequency as a sack-avoidance measure. That’s where the Over 5.5 rushing attempts prop becomes interesting, especially with plus-money odds across our best sportsbooks.

Nix has cleared this line eight times this season, and on three occasions in his past four games. bet365 offers this prop at +115, with our other best sports betting apps ranging between +105 and +110 odds for one of your NFL Wild Card Weekend predictions.

Best odds: +115 via bet365 | Implied probability: 46.51%

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Bo Nix Over 0.5 interceptions thrown (-145)  ⭐⭐⭐⭐

It won’t be all sunshine and roses for the rookie quarterback in a hostile environment, which is why I’m taking the Over on this Nix interception prop against a ball-hawking Buffalo defense.

The Bills' defense averages nearly one interception per outing. The game script could certainly lead to Nix needing to force throws out of desperation to keep his team alive late.

Nix has thrown six interceptions over his past five games. Despite his acumen, a rookie is still a rookie and it’s hard to rule out the possibility of an errant decision at some point in this one. Caesars posts the best odds on this prop at -145.

Best odds: -145 via Caesars | Implied probability: 59.18%

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Broncos vs. Bills expert picks

Bo Nix prop bet odds

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