Chargers vs. Cardinals Prediction, Picks & Odds for Tonight's MNF
The Los Angeles Chargers are 3-1-1 against the spread (ATS), while the Arizona Cardinals are 3-3 ATS entering tonight's Monday Night showdown at State Farm Stadium in Glendale, Ariz. (9 p.m. ET).
The Monday Night Football odds have the Chargers as either 1 or 1.5-point road favorites, with the line decreasing from -2.5.
- The Chargers allow the fewest points per game (13.2), while the Cardinals allow the fourth most (27.2)
- Los Angeles hasn't allowed more than 20 points. The most it allowed (20) came against the Pittsburgh Steelers in Week 3
- Arizona’s loss to Green Bay last week was its 12th straight following a win (it hasn’t won back-to-back games since 2021)
Our Chargers vs. Cardinals prediction focuses on Arizona's chances of pulling off the upset at home.
It's part of the MNF coverage, including our Chargers vs. Cardinals MNF prop bets and Chargers vs. Cardinals anytime touchdown scorer predictions.
Best Chargers vs. Cardinals picks
NFL picks based on the odds from our best NFL betting sites. Odds subject to change.
- Against the spread pick: Cardinals +2.5 (-120 via BetMGM) vs. Chargers ⭐⭐⭐
- Player prop: J.K. Dobbins longest rush Over 17.5 yards (-125 via DraftKings) ⭐⭐⭐⭐
Chargers vs. Cardinals against the spread prediction: Monday Night Football
Cardinals to cover the spread: +2.5 (-120) ⭐⭐⭐
The Cardinals entered Week 6 with one of the most efficient rushing attacks in the league. At that point, Arizona was averaging the fourth-most rushing yards per game (156.4), was third in yards per rush (5.5), second in yards before contact per rush (3.8), and had an 18% 10-yard rushing percentage (best in the league).
Quarterback Kyler Murray was also doing his part to help the running game, averaging an NFL-best 10.6 yards before contact per rush. With opposing defenses fearing his rushing ability so much, the team averaged the fourth-highest yards per rush on zone-read plays (6.9).
Arizona never got the chance to get its running game going last week, falling into a 24-0 early hole to Green Bay after punting on each of its first four possessions.
If the Cardinals are competitive early or take an early lead, their running game should be a difference maker.
Chargers not built to exploit Cardinals’ weaknesses
The Cardinals rank 22nd in passing yards per game allowed (220.3) and are in the bottom three of the league in passing yards allowed per play (7.78).
Chargers quarterback Justin Herbert has eclipsed 200 passing yards just once this season as the team has employed a more run-heavy attack under Jim Harbaugh.
Thus, the Chargers’ 29th-ranked passing attack - that ranks 24th in yards per pass play - does not figure to be equipped to take advantage of one of Arizona’s biggest weaknesses.
Murray loves the underdog role
Murray is 1-6 straight up in his last seven prime-time starts. However, I expect him to relish in this underdog role. He is the second-most profitable quarterback as an underdog since he entered the league, going 27-17-2 ATS as a 'dog.
BetMGM is the only one of our best sports betting sites offering the underdogs at +2.5. While it is not at the key number of three, I do not mind paying up slightly for the extra half-point compared to the other sportsbooks at +2.
Best odds: -120 via BetMGM | Implied probability: 54.55%
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Chargers vs. Cardinals player prop
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J.K. Dobbins longest rush Over 17.5 yards (-125) ⭐⭐⭐⭐
Dobbins has a run-heavy Chargers backfield to himself now that Gus Edwards is on IR. He is coming off a week where he had career-highs in snap rate (73%) and carries (25).
Dobbins has had 17 or more touches in four of his first five games with the Chargers. He faces a Cardinals defense that has allowed 24 explosive runs this season (sixth-most). He has at least one 17-yard run in three of five games, and one of those came in a game where he had his fewest carries of the season (10).
I was tempted to back Dobbins' anytime touchdown scorer odds given that Arizona has allowed eight rushing touchdowns. But those odds were comparable to this longest rush wager.
He should have plenty of opportunities to bust one big run against a defense that has allowed the second-most rushing yards per game to opposing running backs.
Earlier in the week, one could have found Dobbins’ longest rush at 16.5 with standard -110 odds to back the Over. I am still firing on this Over even though some of the value is lost, as a $10 winning wager still pays out $18.
We backed Dobbins' former quarterback to have a big game of his own with our Lamar Jackson MNF player prop bets.
Best odds: -125 via DraftKings | Implied probability: 55.56%
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Chargers vs. Cardinals odds
See all of this week's NFL odds and NFL scores.
Monday Night Football game info
- Matchup: Chargers vs. Cardinals
- Kickoff: 9 p.m. ET
- Where: State Farm Stadium (Glendale, Ariz.)
- How to watch: ESPN+
- Weather: Indoors
- Favorite: Chargers -2.5 (-110 via BetMGM)
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