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Christian McCaffrey registered two touchdowns in two games against the Seahawks for the 49ers in 2023, and we look at whether he'll feast again on Thanksgiving with our Christian McCaffrey player prop predictions based on the best NFL odds.

In a thrilling conclusion to Thanksgiving's tripleheader, the San Francisco 49ers, standing at 7-3, travel to Lumen Field to take on the Seattle Seahawks, currently at 6-4, in a highly anticipated NFC West showdown. This matchup serves as the climactic finale to a day filled with football action, promising an intense battle between these divisional rivals in a game that could significantly impact the NFC West standings. The clash at Lumen Field adds an extra layer of excitement to the holiday as both teams vie for a crucial victory in their quest for divisional supremacy.

San Francisco is coming off a straightforward 27-14 win over the Tampa Bay Buccaneers at home last week. Brock Purdy had a massive day with 333 passing yards and three touchdowns. Meanwhile, Christian McCaffrey ran 21 times for 78 yards, and Brandon Aiyuk caught five passes for 156 yards and a touchdown.

On the other side, Seattle lost a heartbreaking one-point game to the Los Angeles Rams at SoFi Stadium in Week 11. The Seahawks enter this game with concerns about quarterback Geno Smith’s elbow after a short week.

To accompany our NFL Thanksgiving predictions49ers vs. Seahawks predictions, 49ers vs. Seahawks prop bets, and Brock Purdy player props, here are our best Christian McCaffrey player props for the San Francisco 49ers vs. Seattle Seahawks Week 12 Thanksgiving matchup (odds via our best NFL betting sites; pick confidence based on a 1-to-5-star scale).

Christian McCaffrey NFL player prop predictions for Thanksgiving

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Christian McCaffrey player props for Thanksgiving

Christian McCaffrey Over 74.5 rushing yards (-110 via bet365) ⭐⭐⭐⭐

CMC feasted on this Seattle defense when he faced them with the Niners last season. In two games (regular and postseason), McCaffrey rushed for a combined 227 yards against the Seahawks, including 108 yards at Lumen Field in a Thursday night game last December.

McCaffrey is the leading rusher in the league this season with 825 yards, an average of 82.5 yards per game. Head coach Kyle Shanahan will target Seattle's run defense, as it's easier to exploit than the secondary.

On a short week, don’t be surprised if the Niners’ offense rushes for 40-plus attempts, and CMC will be the beneficiary of it.   

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Christian McCaffrey Over 32.5 receiving yards (-114 via FanDuel) ⭐⭐⭐

Christian McCaffrey has 43 receptions for 364 yards this season, which is an average of 36.4 yards per game. According to Next Gen Stats, CMC leads all running backs with 25 targets, 20 receptions, and 177 yards when aligned wide or in the slot this year. He is a threat wherever he lines up on offense.

The 49ers are 11-0 when McCaffrey has at least 20 scrimmage touches since he joined the team last season (including the postseason). Meanwhile, they are 8-5 when CMC has fewer than 20 touches, including all three of their losses this season.

McCaffrey has 1,189 scrimmage yards through 10 games this year and has hit the Over on this total in half of the games he has played.

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Christian McCaffrey 2+ touchdowns (+220 via Caesars) ⭐⭐⭐

No player has scored more touchdowns in the NFL than McCaffrey this season (14). CMC has nine rushing scores and five receiving touchdowns so far.

There have been three games when he has scored multiple touchdowns and only one game when he failed to find the endzone. Because of his success at scoring, his odds as an anytime touchdown scorer are short. The best price is -200.

However, this Seattle defense could set him up for a big night, especially if the 49ers can establish their run game early.

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Christian McCaffrey Thanksgiving Day player props made 11/23/2023 at 5 a.m. ET

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