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Kansas City Chiefs quarterback Patrick Mahomes (15) signals against the Baltimore Ravens as we offer our best Ravens vs. Chiefs prediction and expert picks for tonight's NFL season opener.
Kansas City Chiefs quarterback Patrick Mahomes (15) signals against the Baltimore Ravens. Photo by Tommy Gilligan / Imagn Images.

At long last, the NFL regular season opens tonight when the Kansas City Chiefs host the Baltimore Ravens at 8:20 p.m. ET (NBC), as we offer our Ravens vs. Chiefs prediction and expert picks for this AFC Championship rematch.

The Chiefs are 3-point favorites by the latest Ravens vs. Chiefs odds, which kicks off a busy week for our NFL predictions for Week 1.

Both of these teams enter the season as the favorites by the Super Bowl odds in the AFC, but only one will open the year 1-0 with the Lombardi Trophy in their sights.

Best Ravens vs. Chiefs picks

NFL picks based on the odds from our best NFL betting sites. Odds subject to change.

Ravens vs. Chiefs spread prediction: Week 1

Chiefs to cover the spread: -3 (+100) ⭐⭐⭐⭐

While the Patrick Mahomes factor is always front and center, his influence in the opener will probably be matched by Lamar Jackson, last season's MVP. Mahomes is the NFL MVP odds front-runner this year, while Jackson is attempting to win his second straight award. 

Both teams will almost invariably be in the mix to represent the AFC in Super Bowl 59, but it will take the Ravens slightly longer to adjust and adapt to their substantial personnel changes since last season's run to the AFC Championship Game.  

Ravens' new-look defense, and offensive line needs time to gel 

The departures of Pro Bowl linebacker Patrick Queen and Jadeveon Clowney change the complexion of the Ravens' pass rush and overall defensive look.

Zach Orr will step into the fire in his first game as Baltimore's defensive coordinator, facing the NFL's best quarterback, arguably the best tight end, and a rookie wide receiver in Xavier Worthy blessed with more pace than a cheetah in his prime.

Talk about a baptism of fire. 

Kevin Zeitler and John Simpson are also gone, putting pressure on a new-look offensive line. While Jackson is more elusive than a lively jackrabbit, it will be more challenging working behind three new starters.

Left guard Andrew Vorhees hasn't played an NFL game, right guard Daniel Faalele has been asked to play in a new position, and veteran right tackle Patrick Mekari has started 36 games over his five-year career. 

Last season, the Chiefs were 8-5 against the spread as 3-point favorites or more and they won 10 of 16 games when favored on the moneyline.

I'd think twice about taking the Chiefs if the line moves to -3.5, but a field goal spread is too alluring to bypass. 

The +100 odds will yield a $10 profit on a winning $10 bet. 

Best odds: +100 via bet365 | Implied probability: 50%

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Ravens vs. Chiefs player prop

Patrick Mahomes Over 20.5 rushing yards (-113) ⭐⭐⭐⭐

Mahomes will be ready to test the Ravens' new-look defense with his feet if the opportunity presents itself. He ran for at least 21 yards in 10 of 16 contests last season and had one additional game with a 20-yard run. 

Mahomes opened last season with four straight games of at least 28 rushing yards. He eclipsed the 21-yard barrier in six of the first seven contests and eight of 10.

The -113 odds at FanDuel will yield a $8.85 profit on a winning $10 wager. Our FanDuel promo code offers the best price across our best sports betting sites

Our Andrew Brennan has three more picks with his Ravens vs. Chiefs player props.

Best odds: -113 via FanDuel | Implied probability: 53.05%

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Ravens vs. Chiefs odds

See all of this week's NFL odds and NFL scores.

Ravens vs. Chiefs game info

  • When: Thursday, Sept. 5
  • Kickoff: 8:20 p.m. ET
  • Where: GEHA Field at Arrowhead Stadium (Kansas City)
  • How to watch: NBC, Peacock (streaming)
  • Weather: 86 degrees, 3% chance of precipitation, 6 mph W, 43% humidity
  • Favorite: Chiefs (-149 via BetMGM)

NFL betting odds pages

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