Top Expert Betting Picks for NFL Week 15

Check out our NFL Week 15 expert picks for the best against the spread and Over/Under bets.

COVID-19 has wreaked havoc on the NFL Week 15 schedule. With three game postponements and some teams dealing with numerous starters in COVID protocols, it can be difficult to sift through all the news. However, there are a bunch of games that are still on track to be played at their regular start times.

Here’s a look at the top against the spread and Over/Under picks for Week 15 from our team of NFL betting experts (odds via DraftKings except where otherwise noted; pick confidence based on a one-to-five-star scale).

Top NFL Week 15 Expert Picks

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SEE ALSO: Top Expert NFL Prop Picks for Week 15

Top NFL Week 15 ATS Picks

Rams -5.5 (-110 via FanDuel)

Note: This game was rescheduled to Dec. 21 at 7 p.m. ET

The public loves to romanticize the Seahawks for some reason. Other than Pete Carroll, Russell Wilson, and the same ugly uniforms, their team is absolutely unrecognizable from the one which dominated the NFL so so many years.

Seattle is 26th in defensive DVOA and has been the worst secondary in football going on for two years now. Matthew Stafford's elbow appears to be healthy again with a 127.2 passer rating, six touchdowns, and no interceptions over the past two weeks, and he should go to town on this secondary. Though some defenders have trickled in and out of the lineup for L.A., it has still proven mighty capable this year and did a great job against Arizona in Week 14. With the delay in the game and the Rams potentially getting some starters back because of it, it might be a good idea to jump on this line now. - Ducey

Saints +11.5 (-115)

Have oddsmakers not seen the Saints face the Bucs in regular-season action of late? New Orleans beat Tampa Bay twice last year before losing in the playoffs, and then 36-27 in Week 8 this season. That Saints defense seems to give Tom Brady trouble due to their ability to play man to man and get interior pressure.

Do I think New Orleans goes to Tampa and wins here? Absolutely not, but the Saints are a vastly better offense with a healthy Alvin Kamara. He returned from injury last week and the Saints improved to 6-3 with him in the lineup in 2021 by blasting the Jets. In addition, New Orleans is trending toward getting fellow tailback Mark Ingram, Pro Bowl right tackle Ryan Ramczyk, and defensive end Cameron Jordan all back from injury/COVID. Bucs running back Leonard Fournette is questionable and their secondary is quite banged up. I think New Orleans can stay within 11. - Jordan

Jaguars -5 (-110)

The Jags did the right thing by firing Urban Meyer. However, Jacksonville is still a bad team that doesn't have a lot going for them. Trevor Lawrence has thrown more interceptions than touchdowns, and the roster simply doesn't offer any solutions to help him.

Still, the Texans are worse. Davis Mills might come out and throw four picks, or a bunch of completions in a row, and it doesn't matter. They've lost by seven points or more in all but one game since Oct. 10. In a battle of bad teams, take the Jags.- Lipka

Bengals +3 (-110 vs BetMGM)

Vegas has sided with the Broncos as they are the home side and the team with two victories in their last three games. The Bengals are in the midst of a two-game losing streak, but not all slumps are created equal. Cincinnati dropped two close battles with potential playoff teams  (L.A. Chargers, San Francisco) and were very close to pulling out both games. 

Both clubs carry 7-6 records, but the Bengals own the more dynamic offense, a run defense that ranks 10th in DVOA, and a 4-2 road record. Expect the Bengals to cover. - McClymont

Top NFL Week 15 O/U Picks

Bengals-Broncos Under 44.5 (-115)

I am in love with this total. The Bengals and Broncos both run the ball more than 42% of the time to rank in the top half of the NFL, and both are incredibly slow-paced. How slow-paced, you ask? Well, the Bengals rank second-to-last in seconds per play, while Denver ranks 28th. In the second half, they fall even lower — and even when Denver has trailed by seven or more this year it's still ranked 26th in pace.

These defenses have had their moments, but we can at least say with certainty that the Bengals come into this one at a position of strength considering they are fourth in rush yards per game against. I think this will be a hard one to watch with so few points. - Ducey

Cardinals-Lions Under 47.5 (-115)

It will be a short week for Arizona after losing to the Los Angeles Rams on Monday night, and I absolutely believe that will have an effect early on that Cardinals offense. Murray will be without Pro Bowl receiver DeAndre Hopkins due to injury and maybe running back James Conner, too. Conner has been a monster with 16 combined TDs. The Lions are 30th in points per game and their two best players on that side of the ball, running back D’Andre Swift and tight end TJ Hockenson, are expected to miss another game.

I went Under in Detroit’s game in Denver last week, and the Lions compiled by scoring only 10 points but they allowed 38 to see that total go Over. Detroit’s defense has been very respectable for the most part otherwise. There won't be too many points in this one. - Jordan

Panthers-Bills Under 44.5 (-105)

Time and time again we've seen teams that rely too much on their quarterback fall apart at inopportune moments. The Bills have been that team the last two years despite a great set of receivers and offensive coordinator. The offensive line and lack of star talent at running back have made it difficult to be more, and the Bills are on the slide now that opposing teams have keyed in on trends.

The Panthers are certainly not the most dangerous team right now, but I like both teams to engage in a defensive battle. For all the Panthers warts, they do have the top-ranked passing defense by total yards and the second in total yards. - Lipka

Falcons-49ers Over 45.5 (-110 via BetMGM)

If there’s one thing we can expect out of Falcons games, it’s points. Roughly 67% of the public money is on the Over, and for good reason. This mark has been surpassed in eight of the Falcons’ games this season, including four of their last six.  

The 49ers’ offense has been red-hot, averaging 28.8 points in their last five games. Head coach Kyle Shanahan now faces his former team and a Falcons squad that gives up an average of 27.2 points per game. The Niners’ last three games have topped the 46-point total. 

Many sites have the line at 46.5. Take the extra point of insurance at BetMGM. - McClymont

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