Top Expert Betting Picks for NFL Week 10

Sportsbook Review

Last Updated: November 12, 2021 11:02 AM EST • 4 min 40 sec read. Twitter link Google News Link

Check out our NFL Week 10 expert picks for the best ATS and O/U bets, including the Under in the Seahawks and Packers game.

A number of key players are out for Week 10 while some major stars, including Russell Wilson, make their return to the field.

Here’s a look at the top against the spread and Over/Under picks for Week 10 from our team of betting experts (odds via DraftKings, FanDuel, SI Sportsbook):

Kenny Ducey: Jets +12 (-110 at DraftKings); Seahawks at Packers Under 49 (-110 at DK)Mike McClymont: Packers -3.5 (+100 at SI Sportsbook); Seahawks at Packers Under 49 (-110 at FanDuel)Ian Wharton: Titans -3 (-110 at DK); Bills at Jets Over 47.5 (-105 at DK)Matt Jordan: Patriots -2.5 (-108 at FanDuel); Eagles at Broncos Under 46 (-125 at DK)

Top ATS Week 10 Expert Picks

Jets +12 (-110) vs. Bills

The public keeps pushing this line further and further away from the Jets, but I think New York has what it takes to keep this game close.

The Buffalo Bills have ranked atop the league in defensive DVOA this year, but the Jets have proven on back-to-back occasions now that they are not an offense to be trifled with. Mike LaFleur's move to the coaching booth has done wonders for this offense, which has been calling more pass plays and working in some exciting gadget plays. Given the fact that Josh Johnson was able to step in and throw for three touchdowns on a decent Colts defense, I see no reason why the Jets can't score the ball here given their success in the last two weeks.

When you mix in an offense that looked ridiculously flat against the lowly Jaguars, I think you get a cover here. -Ducey

Packers -3.5 (+100) vs. Seahawks

This play is, obviously, contingent on the availability of Green Bay Packers quarterback Aaron Rodgers. If he is cleared to return to action, the 2020 MVP will be looking to make a statement — this time on the football field. The Rodgers-led Packers are an incredible 7-0 after a loss under head coach Matt LaFleur and the star QB has thrown 16 touchdowns and zero interceptions in those games. Rodgers has thrown four touchdown passes in each of the past four games after a defeat.

The Seattle Seahawks have struggled in recent trips to Lambeau Field. The Seahawks are 0-6-1 against the spread in their last seven games in Green Bay and are 0-5-1 ATS in the past six matchups with the Packers. -McClymont

Titans -3 (-110) vs. Saints

The New Orleans Saints finally had a three-game winning streak snapped this past week as Atlanta shocked them with a last-minute comeback. This roster is so good for the Saints that they're able to compete with the likes of Trevor Siemian at quarterback. But the bell is about to toll for the Saints as the red-hot Titans come to town. Not to mention, the Saints are going to be without star running back Alvin Kamara.

Tennessee has legitimately been a top-two team in the NFL over the last six weeks. It is winning and covering the spread like clockwork. I expect a close game, but New Orleans will fade away as this one progresses since it simply lacks the talent at quarterback and receiver needed in addition to Kamara being sidelined. -Wharton

Patriots -2.5 (-108) vs. Browns

The best running back in the NFL is Tennessee’s Derrick Henry and he’s the most important one to his team without question. One could argue that No. 2 is Nick Chubb to Cleveland. Chubb tested positive for COVID this week and will be sidelined Sunday.

Since the start of the 2020 season, the Browns are 13-6 and average 27.3 points in games Chubb has played and are 3-3 and average 18.8 points when he sits. Backup Browns RB Kareem Hunt is out injured so Cleveland will be on its third-stringer, while quarterback Baker Mayfield is playing through both shoulder and foot injuries. In addition, top wideout Jarvis Landry is banged up. The Patriots have won and covered three straight games since starting 2-4 straight up and ATS. -Jordan

Top Over/Under Week 10 Expert Picks

Seahawks vs. Packers Under 49 (-110)

Chris Carson returned to practice this week and it appears he's trending toward playing against the Packers. If this is the case, I sense Pete Carroll will lean on the run heavily, as he's done in the past, which should lead this game to go Under this very high total.

You have the added element of rust with Wilson and Rodgers, who could be eased back into action. You also have a Packers defense that's been playing incredibly well of late, and a Seahawks defense that has been fantastic against the run this year. I just don't see both of these defenses letting the floodgates open, especially in a game where the run should be popular. -Ducey

Seahawks vs. Packers Under 49 (-110)

Staying with Packers-Seahawks, not only is Rodgers expected back after a one-week absence, but Wilson is also set to return after he missed three games with an injury to his throwing hand. Normally, a matchup between Rodgers and Wilson would equal plenty of points, but Rodgers has admitted his fitness might be in question after a bout with COVID-19 and Wilson had a pin removed from his surgically repaired finger just two weeks ago.

The trends point to the Under as well. The Under is 6-0 in the Packers’ last six games, 5-0 in the Seahawks’ last five games as an underdog, and 4-0 in Seattle’s last four games on the road. A Packers total has surpassed 49 points just twice this season. -McClymont

Bills vs. Jets Over 47.5 (-105)

The likelihood that Mike White is better than Zach Wilson is relatively low but not impossible. White was stellar in his first career start, and the stark difference between how the Jets' offense ran with him instead of Wilson must be scary for New York fans. If White impresses once more, and this time against a solid Bills defense, will he actually compete for the starting job?

Much would need to go right for that to happen. Buffalo and New York look primed for a higher-scoring game than what the line suggests. The Bills have an elite offense, and the Jets are now competent. -Wharton

Eagles vs. Broncos Under 46 (-125)

Often at this time of year, we’d lean Under for a game in Denver because it’s about time for winter to hit there. But it will be unseasonably nice in the Mile High City on Sunday. This Under is more about the shaky quarterback play on both sides with Jalen Hurts of the Eagles and Denver's Teddy Bridgewater getting the starts. Hurts is a good runner but has hit the 200-yard passing mark once in the past five games.

Denver has a very good defense that just shut down the high-powered Cowboys in Week 9. In addition, the Broncos have faced four teams this season that had a losing record at the time. The Under is 4-0 in those contests with the Broncos allowing an average of 9.0 points per game. Broncos games overall average a scant 37.8 ppg on the season, which is the lowest number in the league. -Jordan