NFL Week 10 Odds & Betting Lines: Spread, Moneyline, Over/Under for All 14 Games

The NFL odds for Week 10 are out, and things slow down with just 14 games on the slate. Our best NFL betting sites have been busy as we move past our Thursday nighter and head into the Weekend.

• The week opened with a game that might be the best of the week as the Thursday Night Football odds favorite Baltimore Ravens edged past the Cincinnati Bengals, 35-34, in a thriller
• Fußball! The final international game of the season as the New York Giants and Carolina Panthers square off at Allianz Arena in Munich at 9:30 a.m. ET on NFL Network (sorry, Germany - we'll do better next time, I hope)
• The Sunday Night Football odds have a couple of division leaders squaring off as the Detroit Lions and Houston Texans clash (8:20 p.m. ET, NBC/Peacock)
• The Monday Night Football odds have a cross-conference tilt between the Miami Dolphins and Los Angeles Rams (8:15 p.m. ET, ESPN)
• The Cleveland Browns, Green Bay Packers, Las Vegas Raiders, and Seattle Seahawks are on bye

NFL Week 10 odd and lines

There's an advantage to betting NFL odds early and trying to beat the closing line in NFL markets. The closer you wait to Sunday to make your NFL picks, the more difficult it becomes to identify edges and secure the best price on a side or total.

That's why it's important to start monitoring the NFL opening odds each week as soon as possible. A proactive approach will aid your long-term success.

Best NFL Week 10 spreads

(odds via DraftKings)

• Divisional rivalry games: Bengals vs. Ravens, Falcons vs. Saints, Broncos vs. Chiefs, Eagles vs. Cowboys
• The Saints fired head coach Dennis Allen on Monday with the spread growing in the Falcons' favor (from Saints +1 to Saints +3.5)
• Home favorites and underdogs are equally split on the slate at open, with seven games coming in on each side of the ledger
• The Cowboys were one such favorite, opening at +2.5; Dak Prescott's injury has moved the line to +7.5
• Biggest opening spread: the Super Bowl odds favorite Chiefs (-9.5) against the visiting Broncos, which has been bet down to -7.5 heading into the weekend
• ATS leaders heading into Week 10: Lions (7-1), Commanders (7-1-1), Colts (7-2), Steelers (6-2), Vikings (6-2)
• ATS losers heading into Week 10: Titans (1-7), Panthers (2-7), Cowboys (2-6), Dolphins (2-6), Seahawks (2-6-1)

Bet $5, Get $150 + $1K Deposit Bonus

Terms and conditions apply.

Claim $150

Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission. 21+. Gambling can be addictive, please play responsibly

Best NFL Week 10 moneylines

(odds via FanDuel)

The last few weeks, we've asked questions during the moneyline portion of these odds, but there are fewer questions this week.

• With Joe Flacco back under center for the Colts, will they be able to put up a better fight against the top dogs of the AFC?
• They didn't look great against the Vikings in Week 9; Flacco very much looked his age and it's not shocking to see the Bills pull away a bit
• This would be a question if the Steelers weren't on a Week 9 bye, but Russell Wilson's first two starts were wins against the Jets and Giants: is this team good enough to hang with the likes of the Commanders?
• How will the Texans fare with the Stefon Diggs injury adding another blow to a banged-up offensive corps already missing Nico Collins?
• Houston looked anemic against New York on Thursday Night Football, struggling to move the ball through the air. Collins is able to return in Week 9, but his availability is unknown
• Will Tua return to form for the Dolphins, or is this season destined to be mired in mediocre play under center?
• The Fins took the loss, but Tua looked alright in guiding the team back from deficit to give it a shot at winning against a major division rival. May be too little, too late for Miami.

Win $150 + NBA League Pass 🏀

New customers only. Deposit min. $5. Place first bet of $5+ and win $150 in Bonus Bets (within 72 hours).

Claim $150

Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission. 21+. Gambling can be addictive, please play responsibly

Best NFL Week 10 Over/Unders

(Odds via bet365)

• Over leaders heading into Week 10: Ravens (8-1); Panthers (7-2), Bucs (6-3)
• Under leaders heading into Week 10: Chargers (1-7); Texans (2-7), Giants, Colts, Browns (3-6)
• Opening market lows: Titans-Chargers is the only game listed at fewer than 40 points, clocking in at 38; last year in Week 10, five games were lined below 40
• Friday updates: Titans-Chargers and Patriots-Bears head into the weekend tied at a low-mark 39 points
• Opening market highs: Bengals-Ravens and Dolphins-Rams bookend the week with 49.5s
• Friday updates: the Bengals-Ravens opened with an Over on Thursday after closing at 53; next up are the 49ers-Bucs (50.5) and Fins-Rams (50)

Bet $5, Get $150 in Bonus Bets

Deposit required. Bonus Bets wager excluded from returns. T&Cs, time limits and exclusions apply. Gambling problem? Call 1-800-GAMBLER

Claim Now

Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission. 21+. Gambling can be addictive, please play responsibly

NFL betting odds pages

Here are our best NFL betting sites:

• Caesars Promo Code: SBRBONUSDYW | Read our Caesars Review
• BetMGM Bonus Code: SBRBONUS | Read our BetMGM Review
• bet365 Bonus Code: SBRBONUS | Read our bet365 Review
• FanDuel Promo Code | Read our FanDuel Review
• DraftKings Promo Code | Read our DraftKings Review

(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.

Not intended for use in MA.
Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

Related pages

• Best Sports Betting Sites | Best Sportsbook Promos (U.S. only)