NFL Week 4 Odds & Betting Lines: Spread, Moneyline, Over/Under for All 16 Games
The NFL odds for Week 4 were released in the middle of last week. As usual, there was considerable movement across our best NFL betting sites based on the results from Sunday.
This will be the last week without teams on bye, so we have another full 16-game slate for the NFL Week 4 odds. That will conclude with another two games of the Monday Night Football odds as the Miami Dolphins host the Tennessee Titans (ESPN, 7:30 p.m. ET) and the Detroit Lions host the Seattle Seahawks (ABC, 8:15 p.m. ET).
The week's marquee game will be the Sunday Night Football odds showdown between the Buffalo Bills and Baltimore Ravens. Baltimore is a short home favorite against 3-0 Buffalo.
The Kansas City Chiefs remain undefeated and the Super Bowl odds favorites. QB Patrick Mahomes is the consensus NFL MVP odds favorite.
NFL Week 4 odd and lines
When betting on NFL markets, there's an advantage in getting to these early lines and trying to beat any line movements. The closer you wait until Sunday to make your NFL picks, the more difficult it becomes to identify edges and secure the best price on the outcome you wish to bet on.
That's why it's important to start monitoring the NFL opening odds each week as soon as possible. This proactive approach will contribute to your long-term success in your sports betting endeavors.
Best NFL Week 4 spreads
Odds via Caesars.
| Game | Sept. 24 | Opening spread (Sept. 19) |
|---|---|---|
| Cowboys vs. Giants early picks | Cowboys -4 | Cowboys -6.5 |
| Rams vs. Bears | Bears -1.5 | Bears -3 |
| Eagles vs. Buccaneers | Eagles -2.5 | Eagles -1 |
| Vikings vs. Packers | Packers -3 | Packers -2.5 |
| Jaguars vs. Texans | Texans -4.5 | Texans -4.5 |
| Bengals vs. Panthers | Bengals -5.5 | Bengals -7 |
| Steelers vs. Colts | Steelers -1.5 | Colts -1 |
| Saints vs. Falcons | Falcons -1.5 | Falcons -1.5 |
| Broncos vs. Jets | Jets -7.5 | Jets -8 |
| Patriots vs. 49ers | 49ers -10.5 | 49ers -9.5 |
| Commanders vs. Cardinals | Cardinals -5 | Cardinals -5 |
| Browns vs. Raiders | Browns -1 | Browns -1 |
| Chiefs vs. Chargers | Chiefs -8.5 | Chiefs -4 |
| Bills vs. Ravens early picks | Ravens -2.5 | Ravens -1.5 |
| Titans vs. Dolphins early picks | Pick 'em | Dolphins -1.5 |
| Seahawks vs. Lions early picks | Lions -4 | Lions -4 |
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The Thursday Night Football odds between the Cowboys and Giants were among the biggest movers from Week 3. Dallas lost for the second straight week and New York prevailed over the Cleveland Browns. That had the spread shrink by 2.5 points.
Week 3 was a monumental week for underdogs. Dogs of 5.5-plus points have nine outright wins this season and are 13-2 against the spead after a 4-0 straight-up day on Sunday, according to Ben Fawkes.
The Packers, Jets, and Chiefs are the only teams favored by a touchdown or more in Week 3.
Best NFL Week 4 moneylines
Odds via DraftKings.
| Game | Sept. 23 | Opening moneyline (Sept. 19) |
|---|---|---|
| Cowboys vs. Giants | Cowboys -205 | Cowboys -305 |
| Rams vs. Bears | Bears -155 | Bears -170 |
| Eagles vs. Buccaneers | Eagles -135 | Eagles -112 |
| Vikings vs. Packers | Packers -135 | Packers -135 |
| Jaguars vs. Texans | Texans -258 | Texans -230 |
| Bengals vs. Panthers | Bengals -205 | Bengals -345 |
| Steelers vs. Colts | Steelers -125 | Colts -118 |
| Saints vs. Falcons | Falcons -130 | Falcons -112 |
| Broncos vs. Jets | Jets -345 | Jets -360 |
| Patriots vs. 49ers | 49ers -520 | 49ers -520 |
| Commanders vs. Cardinals | Cardinals -185 | Cardinals -218 |
| Browns vs. Raiders | Browns -105 | Browns -118 |
| Chiefs vs. Chargers | Chiefs -410 | Chiefs -192 |
| Bills vs. Ravens | Ravens -130 | Ravens -122 |
| Titans vs. Dolphins | -110 | Dolphins -122 |
| Seahawks vs. Lions | Lions -192 | Lions -198 |
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There are six road favorites on the 16-game Week 4 slate. Oddly, the Minnesota Vikings are not among them as they play the rival Green Bay Packers, who may get QB Jordan Love back from injury.
The Philadelphia Eagles grew as road favorites against the Tampa Bay Buccaneers with the teams experiencing different results on Sunday.
Best NFL Week 4 Over/Unders
Odds via bet365.
| Game | Sept. 23 | Opening Over/Under (Sept. 19) |
|---|---|---|
| Cowboys vs. Giants | 44 (-110/-110) | 43.5 (-110/-110) |
| Rams vs. Bears | 41 (-110/-110) | 42.5 (-110/-110) |
| Eagles vs. Buccaneers | 45 (-110/-110) | 47.5 (-110/-110) |
| Vikings vs. Packers | 43.5 (-110/-110) | OTB |
| Jaguars vs. Texans | 45.5 (-110/-110) | 46 (-110/-110) |
| Bengals vs. Panthers | 47.5 (-110/-110) | 43 (-110/-110) |
| Steelers vs. Colts | 40 (-110/-110) | 41 (-110/-110) |
| Saints vs. Falcons | 42.5 (-110/-110) | 46 (-110/-110) |
| Broncos vs. Jets | 38.5 (-110/-110) | 37.5 (-110/-110) |
| Patriots vs. 49ers | 39.5 (-110/-110) | 40.5 (-110/-110) |
| Commanders vs. Cardinals | 50.5 (-110/-110) | 49.5 (-110/-110) |
| Browns vs. Raiders | 37.5 (-110/-110) | 39 (-110/-110) |
| Chiefs vs. Chargers | 39 (-110/-110) | 43 (-110/-110) |
| Bills vs. Ravens | 45 (-110/-110) | 46 (-110/-110) |
| Titans vs. Dolphins | 37 (-110/-110) | 39.5 (-110/-110) |
| Seahawks vs. Lions | 46.5 (-110/-110) | 48 (-110/-110) |
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The Over/Under betting line for 10 games dropped from Thursday to Monday as a result of Week 3's play. Only the Dallas Cowboys and Baltimore Ravens - owners of two of the NFL's best defenses last season - sport a 3-0 record in favor of the Over after Week 3.
Eight teams have yet to cash an Over ticket this season.
More Week 4 NFL odds
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