Arsenal vs. Real Madrid Prediction Today: Champions League Quarterfinal Best Bets, Expert Picks & Odds

Last updated: April 16, 2025 8:54 AM EDT • 5 min read X Social Google News Link

Someone pinch Arsenal fans, who might still be in dreamland after their team's 3-0 drubbing of Real Madrid in the first leg of the Champions League quarterfinal. Our Real Madrid vs. Arsenal prediction discusses whether or not Los Blancos can pull off the improbable in today's second leg.
The Galacticos have completed their fair share of improbable comebacks over the years, but with our best sports betting sites listing them as long shots to advance, is the current deficit too much? We'll know soon with the second leg kicking off at 3 p.m. ET (Paramount+) today from the Santiago Bernabeu in Madrid.
👉 Want more UCL picks? Check out Gary Pearson's Champions League Quarterfinals best bets
📺 Game info & where to watch Arsenal vs. Real Madrid live today
📅 Date: Wednesday, April 16
🕗 Time: 3 p.m. ET
📍 Location: Santiago Bernabeu (Madrid)
📺 Streaming: Paramount+
📊 Arsenal vs. Real Madrid stats: Records, trends & best odds today
💡 Arsenal vs. Real Madrid prediction & expert picks: Champions League Quarterfinal - Wednesday, April 16
🎯 Score prediction: Real Madrid 2, Arsenal 0
✅ Best bet: Real Madrid moneyline (-130 via DraftKings)
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📰 Arsenal vs. Real Madrid Champions League preview & matchup analysis
There's nothing more dangerous than a team playing with little to lose ... unless that team is Real Madrid at the Santiago Bernabeu. Los Blancos tried to limit the damage in the first leg before a Declan Rice free kick blew the doors wide open. Now, each side is looking to book a spot in the semifinals.
Despite their current poor form, this Real Madrid side will look completely different from the one Carlo Ancelotti fielded last week at the Emirates. They'll look to attack with intent, getting the ball to the feet of the team's quadruple threat up top of Jude Bellingham, Kylian Mbappe, Rodrygo, and Vinicius Junior quickly.
While the hosts appear to be one the world's most talented teams on paper, the squad could struggle to control the game in midfield with Eduardo Camavinga suspended for the second leg. Los Blancos must do something no other club has done this season, which is score three goals against Arsenal to advance.
We believe Real Madrid possesses enough talent to score early and often. It'd take a true Herculean effort to overturn a three-goal deficit in a second leg, but if any team can do it, it's Los Blancos at home. Unfortunately for the Spanish giants, there likely isn't enough fairy dust left in the magic bag to pull off another miracle.
As we alluded to earlier, the Gunners haven't conceded three goals all season, and they don't appear ready to change that. The proceedings could get nervy for Mikel Arteta's men, especially if the hosts pull one back early. But they boast enough talent and tactical discipline to reach the Champions League semifinals.
👉 Check out all of our soccer picks for the Champions League and more.
💰 Arsenal vs. Real Madrid picks & best bets
✅ Against the spread pick: Real Madrid -0.5 (-145 via Caesars) ⭐⭐⭐
✅ Moneyline pick: Real Madrid ML (-130 via DraftKings) ⭐⭐⭐
✅ Over/Under pick: Under 3.5 goals (-169 via Caesars) ⭐⭐⭐⭐
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⚽ Best Arsenal vs. Real Madrid Champions League player prop bet
🔎 Our NEW player prop odds tool can help you find the best betting odds across legal sportsbooks in your area!
🔥 Kylian Mbappe anytime goalscorer ⭐⭐⭐
Real Madrid will take goals from anyone in the second leg after being held scoreless in London. That's presented us with a rare opportunity to grab Mbappe - a world-class forward - at even money as an anytime goalscorer.
Mbappe has already tallied seven goals across 12 Champions League appearances and 32 in all competitions, so he's in fine form.
The Galacticos will be playing on the front foot from the moment the referee's whistle touches his lips to indicate kickoff. Real Madrid simply need to go for it in front of the most restless fans in world football. If the hosts manage to create plenty of chances as expected, the Frenchman is bound to find the back of the net.
🔢 Best odds: +100 via FanDuel
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📡 Arsenal vs. Real Madrid live odds
🛜 Game already started? You can still get in on the action with our best live betting sites.
🚑 Arsenal vs. Real Madrid injury report
🗳️ Who will win Arsenal vs. Real Madrid?
⚽ Best soccer betting sites
Looking to bet on soccer today? Here are the best soccer betting sites as determined by our expert team at Sportsbook Review, along with the best sportsbook promos available for today's Champions League games.
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