Real Madrid vs. Man City Prediction, Pick & UCL Odds: All Eyes on Opening 45

Check out our top Real Madrid vs. Manchester City picks for Tuesday's Champions League Quarterfinal match, with Manchester City the +150 favorite.

Manchester City and Real Madrid clash in a showcase Champions League quarterfinal, with the first leg on Tuesday at  theSantiago Bernabeu, and we have our top Real Madrid vs. Man City prediction and best bet based on the top Champions League odds.

Manchester City and Real Madrid, two of the Champions League's top contenders, are set to collide in a highly anticipated rematch of last season's semifinal.

City hasn't lost in the competition since allowing two late goals to Real Madrid in the 2021-22 semifinals. According to our best sports betting sites, they are the consensus favorite to defend their title and are currently riding an impressive 21-match unbeaten streak spanning nearly two years in the Champions League.

On the other hand, Real Madrid has maintained a perfect record at home in La Liga this season, securing an impressive 41 out of 45 possible points at the Bernabeu. The Galácticos have also dominated the Champions League, winning seven out of eight matches.

In their last encounter at the Bernabeu, City salvaged a 1-1 draw thanks to Kevin De Bruyne's 67th-minute equalizer, marking their most recent clash on Madrid's turf. This rematch promises to be a thrilling showdown between two football powerhouses vying for European supremacy.

Accompanying our Arsenal vs. Bayern Munich, PSG vs. Barcelona, and Atletico Madrid vs. Borussia Dortmund predictions, here's our best Real Madrid vs. Man City prediction and soccer picks (odds via our best soccer betting sites; pick confidence based on a 1-to-5-star scale).

Real Madrid vs. Man City game info

  • Date: Tuesday, April 9
  • TV: TNT Sports 2 or Discovery+ App
  • Location: Santiago Bernabeu, Madrid, Spain
  • Weather: Sunny and a high of 61 Fahrenheit
  • Favorite: Manchester City (+150)

Real Madrid vs. Man City odds

Teams Moneyline Spread Total
Manchester City +150 -0.5 (+140) Over 2.5 (-140)
Real Madrid  +185 +0.5 (-190) Under 2.5 (+110)

Real Madrid vs. Man City prediction

Draw at halftime ⭐⭐⭐⭐

Best odds: +125 via bet365

The importance of the opening 45 minutes cannot be overstated, as it will set the tone for the entire tie. While Manchester City would love to leave Spain with a victory, Pep Guardiola and company will also be satisfied with a share of the spoils, particularly considering the circumstances.

City played in the Premier League on Saturday, beating Crystal Palace 4-2 in London, providing just two rest days before their most pivotal contest of the season. City has a large enough squad to cope with the condensed schedule. However, Real Madrid enters Tuesday's first leg on nine days' rest, starkly contrasting the visitor's 48 hours. In addition, City would be pleased to welcome Real Madrid to the Etihad for the second leg on level terms.

City will ensure its defense is watertight and well-organized, prepared to batten down the hatches and absorb Madrid's almost inevitable initial onslaught. Also, Madrid is more productive and lethal after the interval, scoring 11 of 19 Champions League goals in the second half. Considering what's at stake, expect an excessively combative first half devoid of space.

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Real Madrid vs. Man City odds analysis

At +125, bet365 offers the best value of our best sports betting sites for parity after the first half. DraftKings offers +120, while FanDuel has +115 and Caesars +110. A $10 winning bet at bet365 pays out $22.50 and has an implied probability of 44.44%. There won't be much movement on this line in the lead-up to Tuesday's encounter, although the +125 at bet365 might shorten to more closely align with FanDuel and Caesars.

An alternative bet to consider is the full-time draw, trading at +250 at FanDuel, Caesars, and bet365. Look for the match to follow a similar script to the last time these teams met at the Bernabeu, which ended level at one.  

Real Madrid vs. Man City prediction made Sunday at 10:39 a.m. ET.

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