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Uruguay forward Darwin Nunez celebrates his goal as we look at our USA vs. Uruguay picks and predictions
Uruguay forward Darwin Nunez celebrates his goal past Bolivia goalkeeper Guillermo Viscarra. Photo Credit: Vincent Carchietta-USA TODAY Sports.

The Copa America 2024 hosts have a huge challenge in trying to lock up their place in the last eight of the competition, and here are our USA vs. Uruguay predictions for Monday's showdown based on the odds from our best soccer betting sites.

USA’s destiny at Copa America is in their own hands, but they’ve given themselves a huge mountain to climb after their 2-1 defeat to Panama on Thursday.

Gregg Berhalter’s side will secure their qualification for the quarterfinals if they beat Uruguay on Monday, but to do so they will have to stop the tournament’s leading scorers. 

Free-scoring Uruguay put five past Bolivia in their second Group C match. It was La Celeste’s biggest win in the competition in over 60 years. Their eight goals in the first two matches are the most they’ve scored at this stage of the tournament compared to any of their last four appearances at the Copa America.

Uruguay is right behind tournament favorites Argentina and Brazil in the Copa America odds and star Darwin Nunez fronts the Copa America top goal scorer odds.

USA vs. Uruguay predictions for Monday

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USA vs. Uruguay score prediction

Uruguay 3 vs. USA 1

Uruguay is unbeaten in their last six international matches. Five different players scored in their 5-0 win over Bolivia on Thursday, and they had 43 touches inside Bolivia’s box while completing 15 shots from within the penalty area.

Team USA executed the same number of shots from inside the box against the Bolivians in their opener and scored twice. USA’s defensive form has been inconsistent, and they conceded six goals in their two warm-up games before the tournament and shipped two against a Panama side ranking 43rd in the world. The Americans played most of that match with 10 men following the dismissal of Timothy Weah after just 18 minutes.

The sending-off allowed Panama to retain the ball with a huge 73% possession. The Stars and Stripes attempted six shots in that game, their lowest total in the competition so far. Uruguay has averaged three goals a game over their last four contests and conceded just once. La Celeste have lost one of their last ten games and will like their chances against this

The United States are struggling for form and these +2800 odds at bet365 will pay a profit of $280 off a $10 bet if Uruguay wins 3-1. Those odds imply a 3.4% probability. 

Best odds: +2800 via bet365

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USA vs. Uruguay anytime goal scorer prediction

Darwin Nunez, Uruguay

The Liverpool forward is the joint-leading scorer in this tournament with two goals through two games. Nunez has nine shots and is averaging 87 minutes per goal. He scored a hat-trick in La Celeste’s final warm-up match against Mexico.

He is the third Uruguayan this century to score in each of his first two Copa America appearances. Uruguay has made 46 crosses this tournament, creating opportunities for Nunez, who is a big target on offense. This U.S. defense could be inviting for him.

bet365’s odds at +210 offer the best value, implying a 32.3% probability he finds the net again. A winning $10 bet will profit $21 if Nunez gets on the scoresheet. 

Best odds: +210 via bet365

USA vs. Uruguay best bet

Both teams score and no draw

Uruguay has been excellent on offense in recent matches, scoring 12 goals through three games. The Stars and Stripes have scored in each of their last six outings, but they have kept only two clean sheets through eight matches.

The United States need a win to fully guarantee their passage to the knockout stage, so they are going to have to attack the Uruguayan defense. Uruguay failed to score once in 10 matches and has the firepower to expose the U.S., if they choose to operate a high press against the South Americans in search of a goal.

DraftKings’ +195 odds imply a probability of 33.9%, and a $10 bet pays a profit of $19.50 if it hits. 

Best odds: +195 via DraftKings

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USA vs. Uruguay game info

  • When: Monday, July 1, 9 p.m. ET
  • Where: Arrowhead Stadium, Kansas City, MO
  • How to watch: FS1, Fubo
  • Favorite: USA (+155 via DraftKings)

USA-Uruguay predictions made Saturday at 12:19 p.m. ET.

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