College Football Predictions Week 2: Picks & Odds for Marquee Games
Following a Week 1 filled with easy non-conference matchups for the top college football championship odds contenders, the difficulty increases a whole lot in Week 2.
While leaning on our best college football betting sites, we're analyzing a jam-packed schedule with our college football Week 2 odds and predictions. Add to your Saturday with the wide menu of college football player props.
The most significant game of the week is a clash between two college football playoff odds contenders, with Texas facing off with Michigan.
But there are plenty of other intriguing matchups featuring an AP top-25 program. Alabama looks to brush off South Florida after struggling last year with the Bulls. That game is featured in our Week 2 college football expert picks.
The other headline-grabbing contest is the rematch between Nebraska and Colorado. Shedeur Sanders is a Heisman Trophy odds favorite, but the Cornhuskers boast a talented young QB of their own in Dylan Raiola.
College football picks & predictions Week 2
- Tennessee vs. NC State prediction
- South Florida vs. Alabama prediction
- Colorado vs. Nebraska prediction
- Texas Tech vs. Washington State prediction
- Mississippi State vs. Arizona State prediction
Don't miss the rest of our Week 2 college football picks.
College football odds for Saturday
Tennessee vs. NC State odds
Prediction: Tennessee -9 (-110 via DraftKings) vs. NC State ⭐⭐⭐⭐
Terms and conditions apply.
Pick made by Brenden Schaeffer
- When: Saturday, Sept. 7 (7:30 p.m. ET)
- Where: Bank of America Stadium, Charlotte
- How to watch: ABC
- Moneyline: Tennessee (-345) | NC State (+275)
- Spread: Tennessee -10 (-110) | NC State +10 (-110)
- Total: 60.5 (-112/-108)
South Florida vs. Alabama odds
Prediction: Alabama -31 (-110 via BetMGM)⭐⭐⭐⭐
Pick made by Phil Wood
- When: Saturday, Sept. 7 (7 p.m. ET)
- Where: Bryant-Denny Stadium (Tuscaloosa, Ala.)
- How to watch: ESPN
- Moneyline: OFF
- Spread: South Florida +31 (-110) | Alabama -31 (-110)
- Total: 63.5 (-112/-108)
Last year Alabama beat South Florida by a modest 17-3 score, and Jalen Milroe was the third-string QB for the game. Now Milroe's a Heisman contender and Kalen DeBoer is coaching the Crimson Tide. The Bulls have a star QB in Byrum Brown, but their defense is going to be an issue. Alabama beat Western Kentucky 63-0 in Week 1. This line could be -34 by kick.
Colorado vs. Nebraska odds
Prediction: Travis Hunter Over 83.5 receiving yards (-114 via FanDuel) ⭐⭐⭐
Pick made by Mike Spector
- When: Saturday, Sept. 7 (7:30 p.m. ET)
- Where: Memorial Stadium (Lincoln, Neb.)
- How to watch: NBC, Peacock
- Moneyline: Colorado (+215) | Nebraska (-265)
- Spread: Colorado +7.5 (-115) | Nebraska -7.5 (-105)
- Total: 57.5 (-112/-108)
When Colorado beat Nebraska 36-14 in Boulder last season it was at the height of Deion Sanders mania. But the Cornhuskers should be much more competitive in Matt Rhule's second season. Led by freshman QB Dylan Raiola, Nebraska killed UTEP last week while the Buffaloes struggled with North Dakota State. However, I think this will be more like -6.5.
Texas Tech vs. Washington State odds
Prediction: Josh Kelly Over. 69.5 receiving yards (-105 via DraftKings) ⭐⭐⭐
Pick made by Mike Spector
- When: Saturday, Sept. 7 (10 p.m. ET)
- Where: Gesa Field (Pullman, Wash.)
- How to watch: FOX
- Moneyline: Texas Tech (+105) | Washington State (-125)
- Spread: Texas Tech +2 (-112) | Washington State -2 (-108)
- Total: 65.5 (-112/-108)
It's the Mike Leach bowl in Pullman between two teams that scored a lot and allowed a lot of scoring to FCS programs in Week 1. Texas Tech needed OT and a 2-point conversion stop to beat Abilene Christian. Washington State beat Portland State 70-30. Cougars QB John Mateer can toast the Red Raiders in a high-scoring game. This could move to -3 by kick.
Mississippi State vs. Arizona State odds
Prediction: Mississippi State +5.5 (-108 via FanDuel) ⭐⭐⭐⭐
Pick made by Mike Spector
- When: Saturday, Sept. 7 (10:30 p.m. ET)
- Where: Mountain America Stadium (Tempe, Ariz.)
- How to watch: ESPN
- Moneyline: Mississippi State (+200) | Arizona State (-245)
- Spread: Mississippi State +6.5 (-112) | Arizona State -6.5 (-108)
- Total: 59.5 (-110/-110)
These are supposed to be two of the worst Power 4 teams in the country this season. Arizona State's dealing with all kinds of sanctions and Mississippi State is rebuilding under new coach Jeff Lebby. The Sun Devils are coming off a surprising blowout of Wyoming and should remain between -5.5 and -6.5.
College football picks roundup: Week 2
- College football Week 2 upset picks
- College football Week 2 parlay picks
- Big Ten predictions
- SEC predictions
- Big 12 predictions
- College football Week 2 predictions & best bets for Saturday
- College football Week 2 player props
- College football Week 2 expert picks
College football betting odds pages
Here are our best college football betting sites:
- Caesars Promo Code: SBRBONUSDYW | Read our Caesars Review
- BetMGM Bonus Code: SBR1550 | Read our BetMGM Review
- bet365 Bonus Code: SBRBONUS | Read our bet365 Review
- FanDuel Promo Code | Read our FanDuel Review
- DraftKings Promo Code | Read our DraftKings Review
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* Bonuses not applicable in Ontario.
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- Best Sports Betting Sites | Best Sportsbook Promos (U.S. only)
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