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Ohio State Buckeyes wide receiver Emeka Egbuka (2) celebrates as we offer our college football Week 7 predictions.
Ohio State Buckeyes wide receiver Emeka Egbuka (2) celebrates with running back Quinshon Judkins (1). Photo by Joseph Maiorana / Imagn Images.

College football fans have had Saturday circled on their calendars for months, and the biggest weekend of the year has finally arrived as we offer our best college football predictions for Week 7.

A week after Alabama lost in its first week as the No. 1 team by the AP Top 25 poll, the top four teams in the polls this week all face tricky matchups in conference play.

Ohio State enters Saturday as the college football championship odds favorite ahead of a highly anticipated clash with Oregon in a No. 2 vs. No. 3 showdown in Eugene.

Boise State running back Ashton Jeanty is now the Heisman Trophy odds favorite after some struggles from Miami's Cam Ward and other top quarterbacks.

The College Football Playoff odds picture should begin to become a little clearer this week, thanks to several ranked matchups.

College football picks & predictions Week 7

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Don't miss the rest of our Week 7 college football picks.

College football odds for Saturday

College football odds via DraftKings and subject to change. Follow the latest college football scores for line history and matchup info. All times Eastern.

Florida vs. Tennessee odds

Prediction: Tennessee -15.5 (-108 via FanDuel) vs. Florida ⭐⭐⭐

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Pick made by Mike Spector.

  • When: Saturday, Oct. 12 (7 p.m.)
  • Where: Neyland Stadium, Knoxville, Ten.
  • How to watch: ESPN
  • Moneyline: Florida +500 | Tennessee -700
  • Spread: Florida +15 (-108) | Tennessee -15 (-112)
  • Total: 55.5 (-110/-110)

Ohio State vs. Oregon odds

Prediction: Ohio State -3.5 (+100 via BetMGM) vs. Oregon ⭐⭐⭐⭐

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Pick made by Rob Paul.

  • When: Saturday, Oct. 12 (7:30 p.m.)
  • Where: Autzen Stadium, Eugene, Ore.
  • How to watch: NBC
  • Moneyline: Ohio State -155 | Oregon +130
  • Spread: Ohio State -3 (-115) | Oregon +3 (-105)
  • Total: 53 (-112/-108)

Ole Miss vs. LSU odds

Prediction: Ole Miss -3.5 (-105 via BetMGM) vs. LSU ⭐⭐⭐⭐

Pick made by Phil Wood.

  • When: Saturday, Oct. 12 (7:30 p.m.)
  • Where: Tiger Stadium, Baton Rouge, La.
  • How to watch: ABC
  • Moneyline: OTB
  • Spread: Ole Miss -3.5 (-108) | LSU +3.5 (-112)
  • Total: 63.5 (-108/-112)

Kansas State vs. Colorado odds

Prediction: Kansas State -3.5 (-105 via BetMGM) vs. Colorado ⭐⭐⭐

Pick made by Mike Spector.

  • When: Saturday, Oct. 12 (10:15 p.m.)
  • Where: Folsom Field, Boulder, Colo.
  • How to watch: ESPN
  • Moneyline: Kansas State -170 | Colorado +142
  • Spread: Kansas State -3.5 (-112) | Colorado +3.5 (-108)
  • Total: 56.5 (-110/-110)

College football picks roundup: Week 7

College football betting odds pages

Here are our best college football betting sites:

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